{"id":9646,"date":"2024-08-28T16:54:37","date_gmt":"2024-08-28T20:54:37","guid":{"rendered":"https:\/\/www.vielight.com\/?p=9646"},"modified":"2025-08-26T10:57:05","modified_gmt":"2025-08-26T14:57:05","slug":"can-light-penetrate-the-skull","status":"publish","type":"post","link":"https:\/\/www.vielight.com\/blog\/can-light-penetrate-the-skull\/","title":{"rendered":"Can Light Penetrate the Skull?"},"content":{"rendered":"<div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"max-width:1144px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-blend:overlay;--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-text fusion-text-1\"><p><strong data-start=\"282\" data-end=\"342\">Can light penetrate the human skull and reach the brain?<\/strong> This question often arises among both skeptics and scientists.<\/p>\n<p>The answer is <em data-start=\"433\" data-end=\"438\">yes <\/em>but with caveats; this requires an appropriate wavelength (nm) and sufficient irradiance (mW\/cm\u00b2) In this <a href=\"https:\/\/www.youtube.com\/watch?v=Onm07-EPCkw\" target=\"_blank\" rel=\"noopener\">demonstration<\/a> with a real human skull, <a href=\"https:\/\/www.vielight.com\/devices\/\" target=\"_blank\" rel=\"noopener\">the Vielight Neuro<\/a>, emitting 810 nm near-infrared light at an industry-leading irradiance of 250 mW\/cm\u00b2, clearly passes through the skullcap.<\/p>\n<p>With the highest irradiance in the brain photobiomodulation field and the most published research in the industry, Vielight has set the benchmark for depth of penetration and the <a href=\"https:\/\/www.vielight.com\/research\" target=\"_blank\" rel=\"noopener\">most published<\/a> brain photobiomodulation studies.<\/p>\n<p><strong>Watch the video here:<\/strong><\/p>\n<\/div><div class=\"fusion-video fusion-youtube\" style=\"--awb-max-width:1920px;--awb-max-height:1080px;\"><div class=\"video-shortcode\"><lite-youtube videoid=\"Onm07-EPCkw\" class=\"landscape\" params=\"wmode=transparent&autoplay=1&controls=0&enablejsapi=1\" title=\"YouTube video player 1\" width=\"1920\" height=\"1080\" data-thumbnail-size=\"auto\" data-no-cookie=\"off\"><\/lite-youtube><\/div><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:20px;margin-bottom:20px;width:100%;\"><div class=\"fusion-separator-border sep-single sep-solid\" style=\"--awb-height:20px;--awb-amount:20px;--awb-sep-color:#353232;border-color:#353232;border-top-width:1px;\"><\/div><\/div><div class=\"fusion-text fusion-text-2\"><h2>Firstly, why deliver light energy through the skull?<\/h2>\n<p>The discovery that red to near infrared light energy produces beneficial effects within neurons is groundbreaking. Near-infrared light stimulates a photosensitive enzyme, cytochrome c oxidase, that\u2019s found within mitochondria \u2013 which leads to increased cellular energy, leading to a process known as &#8220;brain photobiomodulation&#8221;. By stimulating cytochrome oxidase activity, <a href=\"https:\/\/www.vielight.com\/photobiomodulation-science\/\">transcranial photobiomodulation<\/a> increases neuronal energy levels \u2013 leading to increased gamma brain oscillations, brain plasticity and cognitive flexibility.<sup>[1]<\/sup><\/p>\n<p>However, this non-invasive, chemical-free brain enhancing stimulation wouldn\u2019t be possible, if near infrared light energy couldn\u2019t reach the brain in the first place.<\/p>\n<div id=\"attachment_2088\" style=\"width: 700px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" aria-describedby=\"caption-attachment-2088\" class=\"wp-image-2088 \" src=\"https:\/\/www.vielight.com\/wp-content\/uploads\/2018\/02\/vielightneuro_lightdepthpenetration1.jpg\" alt=\"\" width=\"690\" height=\"228\" srcset=\"https:\/\/www.vielight.com\/wp-content\/uploads\/2018\/02\/vielightneuro_lightdepthpenetration1-200x66.jpg 200w, https:\/\/www.vielight.com\/wp-content\/uploads\/2018\/02\/vielightneuro_lightdepthpenetration1-300x99.jpg 300w, https:\/\/www.vielight.com\/wp-content\/uploads\/2018\/02\/vielightneuro_lightdepthpenetration1-400x132.jpg 400w, https:\/\/www.vielight.com\/wp-content\/uploads\/2018\/02\/vielightneuro_lightdepthpenetration1-500x166.jpg 500w, https:\/\/www.vielight.com\/wp-content\/uploads\/2018\/02\/vielightneuro_lightdepthpenetration1-600x199.jpg 600w, https:\/\/www.vielight.com\/wp-content\/uploads\/2018\/02\/vielightneuro_lightdepthpenetration1-700x232.jpg 700w, https:\/\/www.vielight.com\/wp-content\/uploads\/2018\/02\/vielightneuro_lightdepthpenetration1-768x254.jpg 768w, https:\/\/www.vielight.com\/wp-content\/uploads\/2018\/02\/vielightneuro_lightdepthpenetration1-800x265.jpg 800w, https:\/\/www.vielight.com\/wp-content\/uploads\/2018\/02\/vielightneuro_lightdepthpenetration1-1000x331.jpg 1000w, https:\/\/www.vielight.com\/wp-content\/uploads\/2018\/02\/vielightneuro_lightdepthpenetration1-1024x339.jpg 1024w, https:\/\/www.vielight.com\/wp-content\/uploads\/2018\/02\/vielightneuro_lightdepthpenetration1-1200x397.jpg 1200w, https:\/\/www.vielight.com\/wp-content\/uploads\/2018\/02\/vielightneuro_lightdepthpenetration1.jpg 1920w\" sizes=\"(max-width: 690px) 100vw, 690px\" \/><p id=\"caption-attachment-2088\" class=\"wp-caption-text\">810nm light energy penetration through a human skull with the Vielight Neuro.<\/p><\/div>\n<h2>What is near infrared light energy?<\/h2>\n<p>Near infrared light (NIR) energy is part of the electromagnetic spectrum \u2013 which are waves (or <a href=\"https:\/\/en.wikipedia.org\/wiki\/Photon\" target=\"_blank\" rel=\"noopener\">photons<\/a>) of the\u00a0<a href=\"https:\/\/en.wikipedia.org\/wiki\/Electromagnetic_field\" target=\"_blank\" rel=\"noopener\">electromagnetic field<\/a>, radiating through space, carrying electromagnetic\u00a0<a href=\"https:\/\/en.wikipedia.org\/wiki\/Radiant_energy\" target=\"_blank\" rel=\"noopener\">radiant energy<\/a>. At this day and age, several existing technologies depend on the ability of electromagnetic energy to penetrate solid objects. Several examples include WiFi, mobile data, radar and navigation satellites.<\/p>\n<p><img decoding=\"async\" class=\"aligncenter\" src=\"https:\/\/www.vielight.com\/wp-content\/uploads\/2019\/08\/Figure-1.jpg\" width=\"627\" height=\"278\" \/><\/p>\n<p style=\"text-align: center;\"><strong>Figure 1 <\/strong>The electromagnetic spectrum<\/p>\n<p>The depth or the power of penetration by light energy depends on the wavelength in the electromagnetic spectrum. Thus, the longer the wavelength, the greater the ability for photons to penetrate an object. For example, near infrared light is found around the center of the electromagnetic spectrum.<\/p>\n<hr \/>\n<h2>Does 810 nm or 1064 nm (1070nm) penetrate deeper into the brain?<\/h2>\n<p>According to\u00a0<strong>a transcranial brain photobiomodulation\u00a0<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7039173\/#:~:text=Comparing%20between%20wavelengths%2C%20810%2Dnm%20wavelength%20delivers%20the%20highest%20energy%20deposition%3B%20850%2D%20and%201064%2Dnm%20wavelengths%20deliver%20more%20energy%20than%20670%2D%20and%20980%2Dnm%20wavelengths%20in%20most%20cases\" target=\"_blank\" rel=\"noopener\">(PBM) study by Harvard Medical School<\/a><\/strong>, Department of Psychiatry, the 810nm wavelength has been found to be superior to other wavelengths, which includes higher wavelengths in the 1070nm range for penetration and dosimetry.<\/p>\n<p data-start=\"268\" data-end=\"305\"><span class=\"relative -mx-px my-&#091;-0.2rem&#093; rounded px-px py-&#091;0.2rem&#093; transition-colors duration-100 ease-in-out\">According to this study by Harvard Medical School, the order of penetration and dosimetry effectiveness is:<\/span><\/p>\n<ol>\n<li data-start=\"113\" data-end=\"154\">\n<p data-start=\"115\" data-end=\"154\"><span class=\"relative -mx-px my-&#091;-0.2rem&#093; rounded px-px py-&#091;0.2rem&#093; transition-colors duration-100 ease-in-out\"><strong data-start=\"0\" data-end=\"10\" data-is-only-node=\"\">810\u202fnm<\/strong>\u00a0\u2013 consistently highest across all age groups and regions<\/span><\/p>\n<\/li>\n<li data-start=\"155\" data-end=\"196\">\n<p data-start=\"157\" data-end=\"196\"><span class=\"relative -mx-px my-&#091;-0.2rem&#093; rounded px-px py-&#091;0.2rem&#093; transition-colors duration-100 ease-in-out\"><strong data-start=\"0\" data-end=\"10\" data-is-only-node=\"\">850\u202fnm<\/strong>\u00a0and\u00a0<strong data-start=\"15\" data-end=\"26\">1064\u202fnm<\/strong>\u00a0\u2013 next most effective in most cases<\/span><\/p>\n<\/li>\n<li data-start=\"197\" data-end=\"274\">\n<p data-start=\"199\" data-end=\"274\"><span class=\"relative -mx-px my-&#091;-0.2rem&#093; rounded px-px py-&#091;0.2rem&#093; transition-colors duration-100 ease-in-out\"><strong data-start=\"0\" data-end=\"10\" data-is-only-node=\"\">670\u202fnm<\/strong>\u00a0and\u00a0<strong data-start=\"15\" data-end=\"25\">980\u202fnm<\/strong>\u00a0\u2013 lesser deposition overall<\/span><\/p>\n<\/li>\n<\/ol>\n<p>This Harvard study is also supported by\u00a0<a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbio.201800173#:~:text=The%20distribution%20of%20photon%20fluence%20at%20660%20and%20810%E2%80%89nm%20within%20brain%20were%20much%20wider%20and%20deeper%20than%20980%20and%201064%E2%80%89nm.\" target=\"_blank\" rel=\"noopener\">another brain PBM dosimetry study<\/a>\u00a0by leading Chinese universities, comparing 660 nm, 810 nm, 880 nm and 1064 nm. They discovered that the distribution of photon fluence at 660 and 810\u2009nm within the brain was much wider and deeper than 980 and 1064\u2009nm.<\/p>\n<div id=\"attachment_50452\" class=\"wp-caption aligncenter\">\n<picture><source srcset=\"https:\/\/www.vielight.com\/wp-content\/uploads\/2025\/02\/810nmvs1064nm-810nm-has-a-deeper-fluence-200x140.jpg.webp 200w, https:\/\/www.vielight.com\/wp-content\/uploads\/2025\/02\/810nmvs1064nm-810nm-has-a-deeper-fluence-300x210.jpg.webp 300w, https:\/\/www.vielight.com\/wp-content\/uploads\/2025\/02\/810nmvs1064nm-810nm-has-a-deeper-fluence-400x280.jpg.webp 400w, https:\/\/www.vielight.com\/wp-content\/uploads\/2025\/02\/810nmvs1064nm-810nm-has-a-deeper-fluence.jpg.webp 474w\" type=\"image\/webp\" sizes=\"474px\" data-srcset=\"https:\/\/www.vielight.com\/wp-content\/uploads\/2025\/02\/810nmvs1064nm-810nm-has-a-deeper-fluence-200x140.jpg.webp 200w, https:\/\/www.vielight.com\/wp-content\/uploads\/2025\/02\/810nmvs1064nm-810nm-has-a-deeper-fluence-300x210.jpg.webp 300w, https:\/\/www.vielight.com\/wp-content\/uploads\/2025\/02\/810nmvs1064nm-810nm-has-a-deeper-fluence-400x280.jpg.webp 400w, https:\/\/www.vielight.com\/wp-content\/uploads\/2025\/02\/810nmvs1064nm-810nm-has-a-deeper-fluence.jpg.webp 474w\" \/><img decoding=\"async\" class=\"wp-image-50452 size-full lazyautosizes ls-is-cached lazyloaded\" src=\"https:\/\/www.vielight.com\/wp-content\/uploads\/2025\/02\/810nmvs1064nm-810nm-has-a-deeper-fluence.jpg\" sizes=\"474px\" srcset=\"https:\/\/www.vielight.com\/wp-content\/uploads\/2025\/02\/810nmvs1064nm-810nm-has-a-deeper-fluence-200x140.jpg 200w, https:\/\/www.vielight.com\/wp-content\/uploads\/2025\/02\/810nmvs1064nm-810nm-has-a-deeper-fluence-300x210.jpg 300w, https:\/\/www.vielight.com\/wp-content\/uploads\/2025\/02\/810nmvs1064nm-810nm-has-a-deeper-fluence-400x280.jpg 400w, https:\/\/www.vielight.com\/wp-content\/uploads\/2025\/02\/810nmvs1064nm-810nm-has-a-deeper-fluence.jpg 474w\" alt=\"\" width=\"474\" height=\"332\" aria-describedby=\"caption-attachment-50452\" data-eio=\"p\" data-src=\"https:\/\/www.vielight.com\/wp-content\/uploads\/2025\/02\/810nmvs1064nm-810nm-has-a-deeper-fluence.jpg\" data-srcset=\"https:\/\/www.vielight.com\/wp-content\/uploads\/2025\/02\/810nmvs1064nm-810nm-has-a-deeper-fluence-200x140.jpg 200w, https:\/\/www.vielight.com\/wp-content\/uploads\/2025\/02\/810nmvs1064nm-810nm-has-a-deeper-fluence-300x210.jpg 300w, https:\/\/www.vielight.com\/wp-content\/uploads\/2025\/02\/810nmvs1064nm-810nm-has-a-deeper-fluence-400x280.jpg 400w, https:\/\/www.vielight.com\/wp-content\/uploads\/2025\/02\/810nmvs1064nm-810nm-has-a-deeper-fluence.jpg 474w\" data-sizes=\"auto\" data-eio-rwidth=\"474\" data-eio-rheight=\"332\" \/><\/picture>\n<p id=\"caption-attachment-50452\" class=\"wp-caption-text\">The distribution of photon fluence at 660 nm, 810 nm, 980 nm and 1064\u2009nm. Wang P, Li T. \u201cWhich wavelength is optimal for transcranial low-level laser stimulation?\u201d J. Biophotonics. 2019; 12:e201800173. https:\/\/doi.org\/10.1002\/jbio.201800173<\/p>\n<\/div>\n<p>The differences in dosimetry is supported by a well-established biological principle, the\u00a0<a href=\"https:\/\/www.researchgate.net\/figure\/The-optical-window-The-efficiency-of-light-transmission-through-tissue-Hb_fig3_254263939\" target=\"_blank\" rel=\"noopener\">body\u2019s first optical window<\/a>. While, the 1064 and 1070nm wavelengths are longer and scatter less than 810nm, they are more\u00a0<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3321368\/?#:~:text=Comparing%20this%20to%20the%20absorption%20spectrum%20of%20water%20(which%20peaks%20between%20900%20nm%20and%201100%20nm\" target=\"_blank\" rel=\"noopener\">strongly absorbed by water<\/a>, which is abundant in biological tissues. This increased absorption by water can lead to reduced photonic availability and tissue penetration despite the longer wavelength, which the\u00a0<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7039173\/#:~:text=Comparing%20between%20wavelengths%2C%20810%2Dnm%20wavelength%20delivers%20the%20highest%20energy%20deposition%3B%20850%2D%20and%201064%2Dnm%20wavelengths%20deliver%20more%20energy%20than%20670%2D%20and%20980%2Dnm%20wavelengths%20in%20most%20cases\" target=\"_blank\" rel=\"noopener\">Harvard Medical study<\/a>\u00a0and\u00a0<a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbio.201800173#:~:text=The%20distribution%20of%20photon%20fluence%20at%20660%20and%20810%E2%80%89nm%20within%20brain%20were%20much%20wider%20and%20deeper%20than%20980%20and%201064%E2%80%89nm.\" target=\"_blank\" rel=\"noopener\">Peking Medical University study<\/a>\u00a0reveal.<\/p>\n<div id=\"attachment_25175\" class=\"wp-caption aligncenter\">\n<picture><source srcset=\"https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/07\/optical-window-200x120.jpg.webp 200w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/07\/optical-window-300x180.jpg.webp 300w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/07\/optical-window-400x240.jpg.webp 400w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/07\/optical-window-500x300.jpg.webp 500w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/07\/optical-window-600x360.jpg.webp 600w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/07\/optical-window-700x420.jpg.webp 700w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/07\/optical-window-768x461.jpg.webp 768w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/07\/optical-window-800x480.jpg.webp 800w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/07\/optical-window-1024x614.jpg.webp 1024w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/07\/optical-window.jpg.webp 1117w\" type=\"image\/webp\" sizes=\"775px\" data-srcset=\"https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/07\/optical-window-200x120.jpg.webp 200w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/07\/optical-window-300x180.jpg.webp 300w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/07\/optical-window-400x240.jpg.webp 400w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/07\/optical-window-500x300.jpg.webp 500w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/07\/optical-window-600x360.jpg.webp 600w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/07\/optical-window-700x420.jpg.webp 700w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/07\/optical-window-768x461.jpg.webp 768w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/07\/optical-window-800x480.jpg.webp 800w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/07\/optical-window-1024x614.jpg.webp 1024w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/07\/optical-window.jpg.webp 1117w\" \/><img decoding=\"async\" class=\"wp-image-25175 lazyautosizes ls-is-cached lazyloaded\" src=\"https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/07\/optical-window.jpg\" sizes=\"775px\" srcset=\"https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/07\/optical-window-200x120.jpg 200w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/07\/optical-window-300x180.jpg 300w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/07\/optical-window-400x240.jpg 400w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/07\/optical-window-500x300.jpg 500w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/07\/optical-window-600x360.jpg 600w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/07\/optical-window-700x420.jpg 700w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/07\/optical-window-768x461.jpg 768w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/07\/optical-window-800x480.jpg 800w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/07\/optical-window-1024x614.jpg 1024w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/07\/optical-window.jpg 1117w\" alt=\"\" width=\"775\" height=\"465\" aria-describedby=\"caption-attachment-25175\" data-eio=\"p\" data-src=\"https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/07\/optical-window.jpg\" data-srcset=\"https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/07\/optical-window-200x120.jpg 200w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/07\/optical-window-300x180.jpg 300w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/07\/optical-window-400x240.jpg 400w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/07\/optical-window-500x300.jpg 500w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/07\/optical-window-600x360.jpg 600w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/07\/optical-window-700x420.jpg 700w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/07\/optical-window-768x461.jpg 768w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/07\/optical-window-800x480.jpg 800w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/07\/optical-window-1024x614.jpg 1024w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/07\/optical-window.jpg 1117w\" data-sizes=\"auto\" data-eio-rwidth=\"1117\" data-eio-rheight=\"670\" \/><\/picture>\n<p id=\"caption-attachment-25175\" class=\"wp-caption-text\">The near infrared window or body\u2019s optical window. Image source: Wang, Erica &amp; Kaur, Ramanjot &amp; Fierro, Manuel &amp; Austin, Evan &amp; Jones, Linda &amp; Jagdeo, Jared. (2019). Safety and penetration of light into the brain. 10.1016\/B978-0-12-815305-5.00005-1.<\/p>\n<\/div>\n<ul>\n<li><strong>Water Absorption<\/strong>: Light absorption by water\u00a0<a href=\"http:\/\/www.scholarpedia.org\/article\/Near_infrared_imaging#:~:text=Above%20950%20nm%2C%20water%20absorption%20increases%20significantly.\" target=\"_blank\" rel=\"noopener\">increases significantly\u00a0<strong>beyond ~950 nm<\/strong><\/a>, and water is abundant in biological tissue.\u00a0At 1064 nm, absorption by water becomes substantial, which attenuates the light more than at 810 nm. This increased absorption reduces the effective depth of penetration, especially for energy reaching specific chromophores like cytochrome c oxidase (CCO).<\/li>\n<li><strong>Cytochrome c Oxidase (CCO) Absorption<\/strong>: Mitochondria\u2019s\u00a0<span class=\"oXzekf\" data-huuid=\"14870756495495696457\">CCO\u2019s\u00a0<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC5718323\/#:~:text=It%20is%20known%20that%20the%20absorption%20of,wavelengths%2C%20with%20more%20absorption%20at%20980%20nm.\" target=\"_blank\" rel=\"noopener\">absorption spectrum peaks\u00a0<strong>around 810 nm<\/strong><\/a>, with a notable decrease in absorption beyond 1000 nm.\u00a0<\/span><span class=\"oXzekf\" data-huuid=\"14870756495495698918\">This means that 810 nm light is more readily absorbed by CCO compared to 1070 nm.<\/span><\/li>\n<\/ul>\n<\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:20px;margin-bottom:20px;width:100%;\"><div class=\"fusion-separator-border sep-single sep-solid\" style=\"--awb-height:20px;--awb-amount:20px;border-color:#e0dede;border-top-width:2px;\"><\/div><\/div><div class=\"fusion-text fusion-text-3\"><h2>Expanding on the 810nm light penetration study by Harvard Medical School<\/h2>\n<p>In order to <a href=\"https:\/\/www.vielight.com\/brain-photobiomodulation-devices\/\">reach the brain transcranially<\/a>, NIR light energy must bypass several barriers \u2013 skin, blood, water and bone.<\/p>\n<p>In <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7039173\/\" target=\"_blank\" rel=\"noopener\">a 2020 study<\/a> comparing 810nm with 1070nm by researchers from the Harvard Psychiatry Department, they combined similar tissues together to create a simplified head model. This model contains eight different brain tissues: white matter (WM), gray matter (GM), CSF, skull, muscles, skin\/muscles, fat, and blood vessels.<sup>[5]<\/sup><\/p>\n<p>This study involved the simulation of light deposition at five wavelengths commonly used in NIR applications\u2014670, 810, 850, 980, and 1064 (1070) nm. These wavelengths have been widely used in published studies in photobiomodulation, many of which correspond to the absorption spectra of different tissues within the human body.<\/p>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"size-full wp-image-9966 alignnone\" src=\"https:\/\/www.vielight.com\/wp-content\/uploads\/2019\/08\/light_energy_penetrate_skull_1.png\" alt=\"\" width=\"510\" height=\"789\" srcset=\"https:\/\/www.vielight.com\/wp-content\/uploads\/2019\/08\/light_energy_penetrate_skull_1-194x300.png 194w, https:\/\/www.vielight.com\/wp-content\/uploads\/2019\/08\/light_energy_penetrate_skull_1-200x309.png 200w, https:\/\/www.vielight.com\/wp-content\/uploads\/2019\/08\/light_energy_penetrate_skull_1-400x619.png 400w, https:\/\/www.vielight.com\/wp-content\/uploads\/2019\/08\/light_energy_penetrate_skull_1-500x774.png 500w, https:\/\/www.vielight.com\/wp-content\/uploads\/2019\/08\/light_energy_penetrate_skull_1.png 510w\" sizes=\"(max-width: 510px) 100vw, 510px\" \/><\/p>\n<p style=\"text-align: center;\"><strong>Figure 3<br \/>\n<\/strong>The average (bars) and peak (dots) energy deposition (penetration) after positioning the LED light source.<br \/>\nThe left brain shows the ROIs that receiving the highest (red) and second highest (orange) energy deposition; the right brain shows the energy deposition map on the cortical surface.<br \/>\n<strong>(a)<\/strong> fluence at the F3-F4 sites<br \/>\n<strong>(b)<\/strong> fluence at the \u00a0Fp1\u2013FpZ\u2013Fp2 sites<\/p>\n<p><img decoding=\"async\" class=\"size-full wp-image-9967 aligncenter\" src=\"https:\/\/www.vielight.com\/wp-content\/uploads\/2019\/08\/light_energy_penetrate_skull_2.png\" alt=\"\" width=\"509\" height=\"1069\" srcset=\"https:\/\/www.vielight.com\/wp-content\/uploads\/2019\/08\/light_energy_penetrate_skull_2-143x300.png 143w, https:\/\/www.vielight.com\/wp-content\/uploads\/2019\/08\/light_energy_penetrate_skull_2-200x420.png 200w, https:\/\/www.vielight.com\/wp-content\/uploads\/2019\/08\/light_energy_penetrate_skull_2-400x840.png 400w, https:\/\/www.vielight.com\/wp-content\/uploads\/2019\/08\/light_energy_penetrate_skull_2-488x1024.png 488w, https:\/\/www.vielight.com\/wp-content\/uploads\/2019\/08\/light_energy_penetrate_skull_2-500x1050.png 500w, https:\/\/www.vielight.com\/wp-content\/uploads\/2019\/08\/light_energy_penetrate_skull_2.png 509w\" sizes=\"(max-width: 509px) 100vw, 509px\" \/><\/p>\n<p style=\"text-align: center;\"><strong>Figure 4<br \/>\n<\/strong>The average (bars) and peak (dots) energy deposition (penetration)\u00a0after positioning the intranasal light source in the: (a)\u00a0nostril, (b)\u00a0mid-nose, and (c)\u00a0close to the nose ceiling (in proximity of the <a href=\"https:\/\/en.m.wikipedia.org\/wiki\/Cribriform_plate\" target=\"_blank\" rel=\"noopener\">cribriform plate<\/a>)<br \/>\nThe left brain shows the ROIs that receiving the highest (red) and second highest (orange) energy deposition; the right brain shows the energy deposition map on the cortical surface.<br \/>\n<strong>(a)<\/strong> Nostril position<br \/>\n<strong>(b)<\/strong> Mid-nose position<br \/>\n<strong>(c)<\/strong> Cribiform plate<\/p>\n<p><img decoding=\"async\" class=\" wp-image-9965 aligncenter\" src=\"https:\/\/www.vielight.com\/wp-content\/uploads\/2019\/08\/intranasal_light_energy_penetrate_skull.png\" alt=\"\" width=\"730\" height=\"202\" srcset=\"https:\/\/www.vielight.com\/wp-content\/uploads\/2019\/08\/intranasal_light_energy_penetrate_skull-200x55.png 200w, https:\/\/www.vielight.com\/wp-content\/uploads\/2019\/08\/intranasal_light_energy_penetrate_skull-300x83.png 300w, https:\/\/www.vielight.com\/wp-content\/uploads\/2019\/08\/intranasal_light_energy_penetrate_skull-400x111.png 400w, https:\/\/www.vielight.com\/wp-content\/uploads\/2019\/08\/intranasal_light_energy_penetrate_skull-500x138.png 500w, https:\/\/www.vielight.com\/wp-content\/uploads\/2019\/08\/intranasal_light_energy_penetrate_skull.png 510w\" sizes=\"(max-width: 730px) 100vw, 730px\" \/><\/p>\n<p style=\"text-align: center;\"><strong>Figure 5<\/strong><\/p>\n<p style=\"text-align: center;\">Plots of the normalized energy deposition results for <strong>(a)<\/strong> the nostril illumination, <strong>(b)<\/strong> the mid-nose illumination, and <strong>(c)<\/strong> the cribriform plate illumination.<br \/>\nAll results are simulated with the optical properties at 810 nm.<\/p>\n<p>Conclusively, they found that the wavelength plays an important role in determining the magnitude of the energy deposition. In general, there was a clear trend showing that 810 nm offered the highest light penetration onto the brain, followed closely by 1064 and 850 nm.<\/p>\n<p>Additionally, a\u00a0study done in 2012 by the State University of New York, Downstate Medical Center, compared the transmission of NIR LED light (830nm) versus visible red LED light (633nm) through soft tissue, bone, water and blood.<\/p>\n<p>Here were their results from their study on the penetration of NIR light through a human head<sup>[3]<\/sup>:<\/p>\n<p><img decoding=\"async\" class=\"aligncenter\" src=\"https:\/\/www.vielight.com\/wp-content\/uploads\/2019\/08\/Figure-3.jpg\" width=\"930\" height=\"413\" \/><\/p>\n<p style=\"text-align: center;\"><strong>Figure 3. <\/strong>Percent Penetrance of Light through Coronal Sections of Cadaver Skull, Bone Only.<\/p>\n<p><img decoding=\"async\" class=\"aligncenter\" src=\"https:\/\/www.vielight.com\/wp-content\/uploads\/2019\/08\/Figure-4.jpg\" width=\"861\" height=\"454\" \/><\/p>\n<p style=\"text-align: center;\"><strong>Figure 4. <\/strong>Percent Penetrance of Light through Sagittal Sections of Cadaver Skull with Intact Soft Tissue.<\/p>\n<p><img decoding=\"async\" class=\"aligncenter\" src=\"https:\/\/www.vielight.com\/wp-content\/uploads\/2019\/08\/Figure-5.jpg\" width=\"1244\" height=\"551\" \/><\/p>\n<p style=\"text-align: center;\"><strong>Figure 5. <\/strong>Percent Penetrance of Light through Various Concentrations of Blood.<\/p>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"\" src=\"https:\/\/www.vielight.com\/wp-content\/uploads\/2019\/08\/Figure-6.jpg\" width=\"772\" height=\"432\" \/><\/p>\n<p style=\"text-align: center;\"><strong>Figure 6. <\/strong>Percent Penetrance of Light through Human Cheek in vivo.\u00a0<strong><br \/>\n<\/strong><\/p>\n<p>These findings demonstrate that NIR light measurably penetrates skin, bone and brain tissue in a human head model. On the other hand, there isn&#8217;t as much transmission of red light in the same conditions.<\/p>\n<p>As mentioned earlier, quite a few technologies depend on the diffusion of light energy through these barriers. For example, brain imaging technology known as near infrared spectroscopy (NIRS). NIRS involves detecting changes in blood hemoglobin concentrations associated with neural activity within cortical brain tissue.\u00a0 Fundamentally, this technology is based on the penetration of NIR light through the cranium and into the brain, reaching up to 4 cm of depth.<\/p>\n<\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;width:100%;\"><div class=\"fusion-separator-border sep-single sep-solid\" style=\"--awb-height:20px;--awb-amount:20px;border-color:#e0dede;border-top-width:1px;\"><\/div><\/div><div class=\"fusion-text fusion-text-4\"><h2>Emphasis on the intranasal channel<\/h2>\n<p>The intranasal channel is an important gateway for light energy to reach the ventral prefrontal cortex of the brain. Otherwise, this area is inaccessible through the cranium. Furthermore, the ventral prefrontal cortex plays a role in emotional responses, decision making and self control &#8211; which play important roles in performance and mental balance.<\/p>\n<p>Watch how Vielight&#8217;s patented intranasal technology can reach deep brain structures through the nasal channel:<\/p>\n<\/div><div class=\"fusion-video fusion-youtube\" style=\"--awb-max-width:1920px;--awb-max-height:1080px;--awb-margin-bottom:30px;\"><div class=\"video-shortcode\"><lite-youtube videoid=\"5brNW1BuvYo\" class=\"landscape\" params=\"wmode=transparent&autoplay=1&enablejsapi=1\" title=\"YouTube video player 2\" width=\"1920\" height=\"1080\" data-thumbnail-size=\"auto\" data-no-cookie=\"off\"><\/lite-youtube><\/div><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-bottom:20px;width:100%;\"><div class=\"fusion-separator-border sep-single sep-solid\" style=\"--awb-height:20px;--awb-amount:20px;border-color:#e0dede;border-top-width:1px;\"><\/div><\/div><div class=\"fusion-text fusion-text-5\"><h2>MoreMore emphasis on the intranasal channel<\/h2>\n<p>Additionally, <a href=\"https:\/\/www.researchgate.net\/publication\/273781132_Red_and_NIR_light_dosimetry_in_the_human_deep_brain\" target=\"_blank\" rel=\"noopener\">a study on the intranasal diffusion of NIR light through a human head<\/a> was done by the Institute of Chemical Sciences and Engineering in Switzerland. This study demonstrated that it is possible to illuminate deep brain tissues transcranially and intranasally.<sup>[4] <\/sup>The measurement of the fluence rate distribution was, once again, carried out on a human cadaveric head.<\/p>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"\" src=\"https:\/\/www.vielight.com\/wp-content\/uploads\/2019\/08\/Figure-7.jpg\" width=\"377\" height=\"425\" \/><\/p>\n<p style=\"text-align: center;\"><strong>Figure 7 <\/strong>View on the 3D mesh of the skull<\/p>\n<p>This study quantifies the light distribution within brain tissue when illuminating from the nasal cavity with a controlled energy deposition.<\/p>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"\" src=\"https:\/\/www.vielight.com\/wp-content\/uploads\/2019\/08\/Figure-8.jpg\" width=\"756\" height=\"413\" \/><\/p>\n<p style=\"text-align: center;\"><strong>Figure 8<\/strong> (a) Fluence rate distribution at 671 nm. (b) Fluence rate distribution at 808 nm.<\/p>\n<p>The results obtained from the study suggests that light at 810 nm is the better choice. This is due to less absorption and reduced scattering at 810 nm in all tissue types. The increased light propagation at the 810 nm wavelength improves the penetration and diffusion rate of photons into deeper brain regions.<\/p>\n<p><img decoding=\"async\" class=\"aligncenter\" src=\"https:\/\/www.vielight.com\/wp-content\/uploads\/2018\/02\/vielightneuro_lightdepthpenetration1.jpg\" width=\"788\" height=\"261\" \/><\/p>\n<p style=\"text-align: center;\"><strong>Figure 9<\/strong> Transmission of light energy through a human cadaver with the Vielight Neuro.<\/p>\n<h2>Conclusion<\/h2>\n<p>The penetration of light energy into the brain is highly dependent on the wavelength. In light of this, several studies support the ability of near infrared light (808 &#8211; 820nm) to penetrate through the skull and up to 4 cm into brain tissue. Thus, these studies help to answer the question: &#8220;Can light penetrate the brain?&#8221; with a &#8220;Yes.&#8221;<\/p>\n<p><img decoding=\"async\" class=\" wp-image-12676 aligncenter\" src=\"https:\/\/www.vielight.com\/wp-content\/uploads\/2019\/08\/Can-light-energy-reach-the-brain-x600.jpg\" alt=\"\" width=\"443\" height=\"443\" srcset=\"https:\/\/www.vielight.com\/wp-content\/uploads\/2019\/08\/Can-light-energy-reach-the-brain-x600-66x66.jpg 66w, https:\/\/www.vielight.com\/wp-content\/uploads\/2019\/08\/Can-light-energy-reach-the-brain-x600-100x100.jpg 100w, https:\/\/www.vielight.com\/wp-content\/uploads\/2019\/08\/Can-light-energy-reach-the-brain-x600-150x150.jpg 150w, https:\/\/www.vielight.com\/wp-content\/uploads\/2019\/08\/Can-light-energy-reach-the-brain-x600-200x200.jpg 200w, https:\/\/www.vielight.com\/wp-content\/uploads\/2019\/08\/Can-light-energy-reach-the-brain-x600-300x300.jpg 300w, https:\/\/www.vielight.com\/wp-content\/uploads\/2019\/08\/Can-light-energy-reach-the-brain-x600-400x400.jpg 400w, https:\/\/www.vielight.com\/wp-content\/uploads\/2019\/08\/Can-light-energy-reach-the-brain-x600-500x500.jpg 500w, https:\/\/www.vielight.com\/wp-content\/uploads\/2019\/08\/Can-light-energy-reach-the-brain-x600.jpg 600w\" sizes=\"(max-width: 443px) 100vw, 443px\" \/><\/p>\n<p style=\"text-align: center;\"><strong>Figure 9\u00a0<\/strong>The light penetration difference among different wavelengths and the effects on cellular mechanisms.<\/p>\n<p style=\"text-align: center;\">Only the wavelengths in the near-infrared window of 600\u2013850nm is absorbed by the mitochondrial electron transfer chain and leads to upregulation of the neuronal respiratory capacity. Source : Mol Neurobiol. 2018 Aug; 55(8): 6601\u20136636.<\/p>\n<h3>References<\/h3>\n<ol>\n<li>Gonzalez-Lima, F; Barrett, Douglas; \u201cAugmentation of cognitive brain functions with transcranial lasers\u201d, <em>Frontiers in Systems Neuroscience<\/em> : doi:10.3389\/fnsys.2014.00036<\/li>\n<li>Smith, Andrew M.; Mancini, Michael C.; Nie, Shuming (2009).\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2862008\" target=\"_blank\" rel=\"noopener\">&#8220;Bioimaging: Second window for in vivo imaging&#8221;<\/a>.\u00a0<em>Nature Nanotechnology<\/em>.\u00a0<strong>4<\/strong>(11): 710\u2013711.\u00a0<a href=\"https:\/\/en.wikipedia.org\/wiki\/Digital_object_identifier\" target=\"_blank\" rel=\"noopener\">doi<\/a>:<a href=\"https:\/\/doi.org\/10.1038%2Fnnano.2009.326\" target=\"_blank\" rel=\"noopener\">1038\/nnano.2009.326<\/a>.\u00a0<a href=\"https:\/\/en.wikipedia.org\/wiki\/International_Standard_Serial_Number\" target=\"_blank\" rel=\"noopener\">ISSN<\/a>\u00a0<a href=\"https:\/\/www.worldcat.org\/issn\/1748-3387\" target=\"_blank\" rel=\"noopener\">1748-3387<\/a>.\u00a0<a href=\"https:\/\/en.wikipedia.org\/wiki\/PubMed_Central\" target=\"_blank\" rel=\"noopener\">PMC<\/a>\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2862008\" target=\"_blank\" rel=\"noopener\">2862008<\/a><\/li>\n<li>Jagdeo JR, Adams LE, Brody NI, Siegel DM (2012) Transcranial Red and Near Infrared Light Transmission in a Cadaveric Model. PLoS ONE 7(10): e47460. <a href=\"https:\/\/doi.org\/10.1371\/journal.pone.0047460\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1371\/journal.pone.0047460<\/a><\/li>\n<li>Pitzschke, Andreas &amp; Lovisa, B &amp; Seydoux, O &amp; Zellweger, M &amp; Pfleiderer, M &amp; Tardy, Y &amp; Wagni\u00e8res, Georges. (2015). Red and NIR light dosimetry in the human deep brain. Physics in medicine and biology. 60. 2921-2937. 10.1088\/0031-9155\/60\/7\/2921.<\/li>\n<li>Yuan Y, Cassano P, Pias M, Fang Q. Transcranial photobiomodulation with near-infrared light from childhood to elderliness: simulation of dosimetry. Neurophotonics. 2020 Jan;7(1):015009. doi: 10.1117\/1.NPh.7.1.015009. Epub 2020 Feb 24. PMID: 32118086; PMCID: PMC7039173.<\/li>\n<\/ol>\n<\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":29653,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"bwfblock_default_font":"","inline_featured_image":false,"mc4wp_mailchimp_campaign":[],"footnotes":""},"categories":[16,478,2977,476,475,1031],"tags":[2002,2004,2005,2003],"class_list":["post-9646","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-scientific-research","category-blog","category-brain-stimulation","category-infrared-light-therapy","category-photobiomodulation","category-transcranial-photobiomodulation","tag-can-light-penetrate-the-skull","tag-can-light-reach-the-brain","tag-near-infrared-penetration","tag-nir-light-penetration"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.vielight.com\/wp-json\/wp\/v2\/posts\/9646","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.vielight.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.vielight.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.vielight.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.vielight.com\/wp-json\/wp\/v2\/comments?post=9646"}],"version-history":[{"count":0,"href":"https:\/\/www.vielight.com\/wp-json\/wp\/v2\/posts\/9646\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.vielight.com\/wp-json\/wp\/v2\/media\/29653"}],"wp:attachment":[{"href":"https:\/\/www.vielight.com\/wp-json\/wp\/v2\/media?parent=9646"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.vielight.com\/wp-json\/wp\/v2\/categories?post=9646"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.vielight.com\/wp-json\/wp\/v2\/tags?post=9646"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}