Systemic Photobiomodulation – Vielight Inc

Vielight RX Plus | Medical Device License Expansion! (Upper Respiratory Viral Symptom Recovery)

Vielight Main — Wed, 12 Jun 2024 19:56:31 +0000

World’s First PBM Medical Device License for Upper Respiratory Symptoms Recovery from Viral Infections!

We are honored to announce that Health Canada has expanded our RX-Plus medical device license to encompass the recovery of upper respiratory symptoms in all viral infections, extending beyond Covid-19!

To date, the RX Plus is the only PBM device supported by statistically significant results in a large (n=294) clinical trial for accelerated recovery from viral infection.

Stay tuned for the journal publication, which goes over the mechanisms of how NIR energy can modulate and improve immune responses and accelerate recovery against respiratory-based viral symptoms.

Find our license here: Link

To learn more about our systemic technology: Link

Vielight is a fully-licensed medical device manufacturer (ISO13485 and MDSAP certified).

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Vielight Inc. Receives Health Canada Approval for Treatment of Covid-19 with Near Infrared Device Technology

Vielight Main — Thu, 25 May 2023 13:26:58 +0000

Approval from Canada’s Top Federal Health Agency Followed Positive Clinical Trial Results

We are honored to announce that the Vielight RX Plus device has received medical device approval from Health Canada!

We conducted an n=295 clinical trial for Covid-19 recovery for which the results were statistically significant.

This represents two historic milestones:

The RX Plus is the first medical device to be approved for the treatment of COVID-19 infection.
The RX Plus is the first non-invasive photobiomodulation (PBM) technology to be approved for a major indication.

The RX Plus combines our patented red and near-infrared light technology to accelerate the recovery of adults with COVID-19. We designed it to be non-invasive, portable, and lightweight to meet the needs of those who prefer to recover at home or on-the-go.

Clinical trial results can be found here: https://medrxiv.org/cgi/content/short/2022.06.16.22276503v1
Information on the Health Canada license can be found here: https://health-products.canada.ca/mdall-limh/information?companyId=136815&lang=eng
In the past, we worked with Harvard Medical School on anti-pathogenic research using blue light energy: https://www.vielight.com/research/#anti-viral

The effects of Photobiomodulation on Immunity.

(The text below is based on an article from Liebert A, Bicknell B, Markman W, Kiat H. A Potential Role for Photobiomodulation Therapy in Disease Treatment and Prevention in the Era of COVID-19. Aging Dis. 2020 Dec 1;11(6):1352-1362. doi: 10.14336/AD.2020.0901. PMID: 33269093; PMCID: PMC7673843)

PBM appears to exert pluripotent effects in the modulation of inflammation and immunity [1]. Many studies have demonstrated that PBM modulates inflammation by reducing the pro-inflammatory cytokines (such as IL-1β, IL-6, IL-8, TNF-α) and other inflammatory markers released from activated inflammatory cells, while increasing the anti-inflammatory cytokines (IL-10) [2]. The immuno-modulatory effect of PBM on cytokines regulation and the complement cascade occurs via the POMC pathway, involving regulation of the hypothalamic pituitary axis through the direct modulation of the POMC/melanocortin signalling pathway including a-MSH, a potent anti-inflammatory molecule. The POMC pathway is regulated by PBM [3], which in turn modulates both ACTH and β-opioid, as well as, interestingly, ACE activity [4].

One of the central effects of PBM on the immune response is via the modulation of neutrophil function [5] by balancing neutrophil numbers, improving neutrophil efficiency and modulating the neutrophil extracellular trap formation [6]. Reducing over-accumulation of neutrophils is a major mechanism for the effect of PBM in reducing acute lung inflammation [7]. This is crucial in preventing the cytokine storm cascade in autoimmune diseases. PBM also modulates the ratio of M1 and M2 macrophage phenotypes, reducing pro-inflammatory cytokines and chemokines and increasing anti-inflammatory cytokines and thus balance the inflammatory process [8].

These inflammatory changes facilitated by PBM have profound effects on many body processes. For example, PBM therapy has been shown to modulate peripheral blood mononuclear cells and CD4+ cells to reduce inflammatory effects in multiple sclerosis patients and healthy adults by increasing IL-10 and reducing IFN-γ [9, 10]. PBM reduces the number of inflammatory cells, pro-inflammatory cytokines as well as fibrotic tissue in a mouse model of lung fibrosis [11]. Acute lung inflammation in rats is reduced with PBM to reduce oedema, neutrophil influx and TNF-α, while reducing IL-10 in rats [12].

In an experimental model of induced acute peritonitis in rats, Yu and co-workers [13] showed PBM resulted in lymphocyte proliferation and enhanced lymphocyte ATP synthesis compared to controls, and the 60-day survival rate of the PBM group was double that of the control group (p<0.001). Assis et al [14] further demonstrated the immune modulation capability of PBM, with septic rats treated with PBM exhibiting lower IL-6 activity and decreased atrogin-1 and MuRF-1 immuno-expression (markers of sepsis related muscle catabolic states).

PBM causes mitogenic stimulation responsive lymphocyte proliferation and enhanced lymphocyte ATP synthesis [15]. A plausible mechanism for PBM induced lymphocytic proliferation is through the reaction of light with haemoglobin, resulting in oxygen radical production [16]. Indeed, in immunological cells, PBM induces production of reactive oxygen species, NO or interleukins most often, leading to an anti-inflammatory effect [17]. It is well documented that various immune response processes are highly dependent on cellular energy, the latter being depressed in sepsis and septic shock cases [18, 19]. The mitochondria probably act as photo-acceptors for PBM and robustly reactivate cellular energy synthesis to re-establish ATP levels in a variety of cells including lymphocytes and macrophages, and through several pathways that trigger activation of nucleic acid synthesis and cellular proliferation [20, 21].

Reference

Liebert A, Bicknell B, Markman W, Kiat H. A Potential Role for Photobiomodulation Therapy in Disease Treatment and Prevention in the Era of COVID-19. Aging Dis. 2020 Dec 1;11(6):1352-1362. doi: 10.14336/AD.2020.0901. PMID: 33269093; PMCID: PMC7673843.

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X-Plus 3: Exponential Performance

Vielight Main — Thu, 10 Mar 2022 04:31:29 +0000

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Introducing the X-Plus 3

Whether you are seeking to improve mental performance (brain photobiomodulation) or body resilience and functions (systemic photobiomodulation), the X-Plus 3 on its own or in combination with a Neuro model will go a long way to help you.

Our acute Covid-19 recovery study used a version of the X-Plus 3 for which the results were significantly positive.
You can read more about our acute Covid-19 recovery results here: https://www.medrxiv.org/content/10.1101/2022.06.16.22276503v1

X-Plus 3 Components

The X-Plus 3 consists of 4 main modules: the X-Plus Head module, the X-Plus Body module, and 2 633nm X-Plus nasal applicators.

The X-Plus Head Module

In everyday life and in sports, your visual processing ability, balance, and coordination is crucial. The X-Plus Head module sits comfortably on the occipital lobe and cerebellum, which are the areas of the brain that process these tasks.

The occipital lobe interprets information from the eyes and turns it into the world as a person sees it. It is responsible for visuospatial processing, distance, and depth perception. ^[1].

The cerebellum is another important structure of the brain.

Although the cerebellum accounts for approximately 10% of the brain’s volume, it contains over 50% of the total number of neurons in the brain. The cerebellum is involved in the following functions:

Maintenance of balance and posture. The cerebellum is important for making postural adjustments to maintain balance. It modulates commands to motor neurons to compensate for shifts in body position or changes in load upon muscles. ^[2]

Coordination of voluntary movements. Most movements are composed of different muscle groups acting together in a temporally coordinated fashion. One major function of the cerebellum is to coordinate the timing and force of these different muscle groups to produce fluid limb or body movements.[3]

Motor learning. The cerebellum is important for motor learning. The cerebellum plays a major role in adapting and fine-tuning motor programs to make accurate movements through a trial-and-error process (e.g. learning to hit a baseball or throwing a basketball accurately).^[4]

Combined, the cerebellum and occipital lobe account for much of the brain’s processing ability for movements required for physical performance. Now imagine the ability to stimulate these two brain structures to improve your everyday life and boost athletic and sports performance in a convenient manner without side effects.

X-Plus Intranasal module

The nasal cavity is saturated with blood capillaries. Five major arteries connect directly to the circulatory system ^[5], making it the perfect location for systemic photobiomodulation.

The X-Plus 3 comes with two 633nm intranasal modules, enabling photobiomodulation of the blood capillary-rich nasal passageway. Additionally, our patented clip-on intranasal design enables usage almost anywhere and while on the move.

Why systemic circulation?

Intranasal photobiomodulation improves oxygenation and leads to increased adenosine triphosphate (ATP) levels in various tissues. ^[6]

Light energy absorbed by blood through the photobiomodulation process leads to an increase in nitric oxide (NO) release.^[7]

Nitric oxide is one of the most important factors affecting microcirculation. This leads to increases in vasodilation which contributes to improved oxygen delivery to tissues , which is important for optimizing your health and sports performance.

The result of light-induced photodissociation of oxyhemoglobin also results in a significant enrichment of local tissue oxygenation. ^[8]

The systemic effect of photobiomodulation on circulation could be a consequence of positive alterations in the membrane properties of red blood cells (RBCs). Absorption of red/NIR light affects hydrogen bonds, which could induce structural changes in RBC membrane proteins. ^[9]

This in turn, results in an improvement of RBC structure, ATP content, and osmotic properties. ^[10]

Conclusively, the X-Plus 3 intranasal modules are powerful tools for internalizing photobiomodulation into your circulatory system.

The X-Plus Body module

We hypothesize that the X-Plus Body module could potentially help with the immune system when positioned on the sternum. A version of this has been used in our clinical trial to treat COVID-19, and the findings will be made public soon.

Preprint of Results: Link

Additionally, the X-Plus Body module can be positioned over joints and certain body parts, such as the shoulder or knees to provide anti-inflammatory relief.

Conclusion

The X-Plus 3 is a useful device for improving anyone’s quality of life, but an especially powerful tool for athletes and biohackers to maximize performance. In a competitive world where the smallest difference in mental and physical performance can mean either first place or everything else after, the X-Plus 3 is a powerful tool to try.

References

[1] – Rehman A, Al Khalili Y. Neuroanatomy, Occipital Lobe. [Updated 2021 Jul 31]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK544320/

[2, 3, 4] – Cerebellum (section 3, Chapter 5) neuroscience online: An electronic textbook for the Neurosciences: Department of Neurobiology and Anatomy – the University of Texas Medical School at Houston. Cerebellum (Section 3, Chapter 5) Neuroscience Online: An Electronic Textbook for the Neurosciences | Department of Neurobiology and Anatomy – The University of Texas Medical School at Houston. (n.d.). Retrieved February 20, 2022, from https://nba.uth.tmc.edu/neuroscience/m/s3/chapter05.html#:~:text=The%20cerebellum%20is%20important%20for,in%20order%20to%20maintain%20balance.&text=One%20major%20function%20of%20the,is%20important%20for%20motor%20learning.

[5] – Nguyen JD, Duong H. Anatomy, Head and Neck, Lateral Nasal Artery. [Updated 2021 Nov 21]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK546681/

[6], [7] – Lohr NL, Keszler A, Pratt P, Bienengraber M, Warltier DC, Hogg N. Enhancement of nitric oxide release from nitrosyl hemoglobin and nitrosyl myoglobin by red/near infrared radiation: potential role in cardioprotection. J Mol Cell Cardiol. 2009 Aug;47(2):256-63. doi: 10.1016/j.yjmcc.2009.03.009. Epub 2009 Mar 25. PMID: 19328206; PMCID: PMC4329292.

[8] – Stadler I, Evans R, Kolb B, Naim JO, Narayan V, Buehner N, Lanzafame RJ. In vitro effects of low-level laser irradiation at 660 nm on peripheral blood lymphocytes. Lasers Surg Med. 2000;27(3):255-61. doi: 10.1002/1096-9101(2000)27:3<255::aid-lsm7>3.0.co;2-l. PMID: 11013387.

[9] – Szymborska-Małek K, Komorowska M, Gąsior-Głogowska M. Effects of Near Infrared Radiation on DNA. DLS and ATR-FTIR Study. Spectrochim Acta A Mol Biomol Spectrosc. 2018 Jan 5;188:258-267. doi: 10.1016/j.saa.2017.07.004. Epub 2017 Jul 12. PMID: 28723592.

[10] – Walski T, Dyrda A, Dzik M, Chludzińska L, Tomków T, Mehl J, Detyna J, Gałecka K, Witkiewicz W, Komorowska M. Near infrared light induces post-translational modifications of human red blood cell proteins. Photochem Photobiol Sci. 2015 Nov;14(11):2035-45. doi: 10.1039/c5pp00203f. PMID: 26329012.

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What is Intranasal Systemic Photobiomodulation?

Vielight Main — Fri, 25 Feb 2022 21:15:33 +0000

Home-use Photobiomodulation Device Treatment Outcomes for COVID-19: Results Pre-Print

Intranasal systemic photobiomodulation is the utilization of light energy within the 620nm-750nm (red light) range on the electromagnetic spectrum to irradiate the capillary-rich nasal cavity.

Red light has less penetrative potential than near infrared light (750+nm), therefore a majority of the photons do not bypass the blood capillaries but are absorbed instead.^[1]

The tissue around the nasal cavity has abundant blood capillaries with relatively slow blood flow. Intranasal photobiomodulation improves oxygenation and leads to increased adenosine triphosphate (ATP) levels in various tissues. ^[2]

Light energy absorbed by blood through the photobiomodulation process leads to an increase in nitric oxide (NO) release.^[3]

Nitric oxide is one of the most important factors affecting microcirculation. This leads to increases in vasodilation which contributes to improved oxygen delivery to tissues – which is important for optimizing your health and sports performance.

The result of light-induced photodissociation of oxyhemoglobin also results in significant enrichment of local tissue oxygenation. ^[4]

This in turn, results in an improvement of RBC structure, ATP content and osmotic properties. ^[6]

References

[1] – Pitzschke, Andreas & Lovisa, B & Seydoux, O & Zellweger, M & Pfleiderer, Martin & Tardy, Y & Wagnières, Georges. (2015). Red and NIR light dosimetry in the human deep brain. Physics in medicine and biology. 60. 2921-2937. 10.1088/0031-9155/60/7/2921.

[2], [3] – Lohr NL, Keszler A, Pratt P, Bienengraber M, Warltier DC, Hogg N. Enhancement of nitric oxide release from nitrosyl hemoglobin and nitrosyl myoglobin by red/near infrared radiation: potential role in cardioprotection. J Mol Cell Cardiol. 2009 Aug;47(2):256-63. doi: 10.1016/j.yjmcc.2009.03.009. Epub 2009 Mar 25. PMID: 19328206; PMCID: PMC4329292.

[4] – Stadler I, Evans R, Kolb B, Naim JO, Narayan V, Buehner N, Lanzafame RJ. In vitro effects of low-level laser irradiation at 660 nm on peripheral blood lymphocytes. Lasers Surg Med. 2000;27(3):255-61. doi: 10.1002/1096-9101(2000)27:3<255::aid-lsm7>3.0.co;2-l. PMID: 11013387.

[5] – Szymborska-Małek K, Komorowska M, Gąsior-Głogowska M. Effects of Near Infrared Radiation on DNA. DLS and ATR-FTIR Study. Spectrochim Acta A Mol Biomol Spectrosc. 2018 Jan 5;188:258-267. doi: 10.1016/j.saa.2017.07.004. Epub 2017 Jul 12. PMID: 28723592.

[6] – Walski T, Dyrda A, Dzik M, Chludzińska L, Tomków T, Mehl J, Detyna J, Gałecka K, Witkiewicz W, Komorowska M. Near infrared light induces post-translational modifications of human red blood cell proteins. Photochem Photobiol Sci. 2015 Nov;14(11):2035-45. doi: 10.1039/c5pp00203f. PMID: 26329012.

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