Brain Stimulation – Vielight Inc

Alzheimer’s Disease and Brain Photobiomodulation | Clinical Results with Vielight Neuro

Vielight Main — Thu, 10 Jul 2025 21:21:44 +0000

This article is based on published independent Alzheimer’s research conducted with the Vielight Neuro Gamma by the University of California

Vielight Neuro Gamma

Read the full Alzheimer’s Disease published study with the Vielight Neuro here: Link

Introduction

Alzheimer’s disease (AD) remains one of the most challenging and devastating neurodegenerative conditions affecting millions worldwide. Characterized by progressive cognitive decline, memory loss, and behavioral changes, AD not only affects the individual but also imposes a significant burden on caregivers and healthcare systems. Despite extensive research, effective treatments for AD are still elusive. However, a promising avenue of investigation has emerged in recent years – brain photobiomodulation (PBM).

Brain PBM, also known as transcranial light therapy or low-level light therapy, involves the non-invasive application of high-power density NIR light energy through the scalp, to the brain, stimulating cellular function and promoting tissue repair. While initially explored for its potential in wound healing and pain management, researchers are increasingly investigating its therapeutic effects on neurological disorders, including AD.

Understanding Alzheimer’s Disease

Before delving into the potential of PBM in AD, it’s crucial to grasp the underlying mechanisms of the disease. AD is characterized by the accumulation of beta-amyloid plaques and tau protein tangles in the brain, leading to neuronal dysfunction and eventual cell death. Additionally, oxidative stress, inflammation, and impaired mitochondrial function contribute to the progression of the disease.

The mechanisms of brain photobiomodulation

How Photobiomodulation Works against Alzheimer’s Disease

When near-infrared light energy penetrates the scalp and skull, reaching neuronal tissue – it is absorbed by mitochondria, enhancing cellular metabolism, increasing ATP production, and reducing oxidative stress and inflammation.

The therapeutic effects of PBM in AD are thought to stem from its ability to modulate various cellular processes implicated in the pathogenesis of the disease.

One key mechanism of PBM against AD is the stimulation of mitochondrial function. Mitochondrial dysfunction is a hallmark of AD and is believed to contribute to neuronal degeneration. By enhancing mitochondrial activity, PBM may help improve cellular energy production and mitigate oxidative stress, thereby protecting neurons from damage.

Besides that, by reducing oxidative stress, PBM may mitigate neuronal damage and promote cellular survival. Oxidative stress arises from an imbalance between the production of reactive oxygen species (ROS) and the body’s ability to detoxify them, leading to cellular damage and dysfunction. PBM has been shown to enhance the activity of antioxidant enzymes, such as superoxide dismutase (SOD) and catalase, while simultaneously reducing the production of ROS. This dual effect helps to restore redox balance within neurons, thereby protecting them from oxidative damage and promoting cellular survival. By targeting oxidative stress, PBM may offer neuroprotective benefits in AD, potentially slowing disease progression and preserving cognitive function.

PBM has also been shown to modulate inflammatory pathways, potentially attenuating neuroinflammation, which is another hallmark of AD. This anti-inflammatory effect of PBM holds significant implications for the treatment of AD, as chronic neuroinflammation contributes to neuronal damage and cognitive decline.

Furthermore, PBM has been shown to promote neurogenesis and synaptogenesis, processes essential for maintaining cognitive function and synaptic plasticity. By stimulating the growth of new neurons and strengthening synaptic connections, PBM may help counteract the neuronal loss and synaptic disruption characteristic of AD.

How Does NIR Light Energy Reach the Brain?

In order to deliver NIR energy to the brain through the skull, scalp and hair to trigger photobiomodulation, this requires 3 important factors:

NIR light energy wavelengths: 810nm to 1100nm
– optimal penetrance based on the body’s optical window.
A form factor that bypasses hair and maximizes contact with the scalp
– hair absorbs light energy.
– light energy becomes weaker from distance, according to the inverse square law of light.
Sufficiently high power density/irradiance: 100+ mW/cm²
– sufficient power density/irradiance is required for light energy to penetrate the scalp and bone.

Clinical Evidence of PBM and Alzheimer’s Disease

Several preclinical studies have demonstrated the beneficial effects of PBM in animal models of AD. For instance, a study published in Neurobiology of Aging by De Taboada et al. (2011) showed that transcranial PBM reduced beta-amyloid plaques and improved memory in a mouse model of AD.^[1] Similarly, another study by Yang et al. (2018) in Neurophotonics reported that PBM decreased tau protein hyperphosphorylation and alleviated cognitive deficits in AD mice.^[2]

Clinical Research with the Vielight Neuro Gamma

The Vielight Neuro Gamma

Clinical evidence with the Vielight Neuro suggests that PBM may offer therapeutic benefits in human patients with AD.

A pilot study conducted by Saltmarche et al. (2017) with the Vielight Neuro and published in Journal of Alzheimer’s Disease found that transcranial PBM improved cognitive function and activities of daily living in patients with mild-to-moderate AD.

In 2019, Dr. Linda Chao, a professor in the Departments of Radiology, Biomedical Imaging and Psychiatry at the University of California, verified our 2015 dementia pilot trial with her own independent brain photobiomodulation dementia study with the Vielight Neuro Gamma on participants with dementia.^[2]

Eight participants diagnosed with dementia were randomized to 12 weeks of usual care or home photobiomodulation(PBM) treatments. The PBM treatments were administered at home with the Vielight Neuro Gamma, a brain photobiomodulation device that emits 100 mW/cm² of power density at 810nm and 40hz.

Several types of assessments were used:

Alzheimer’s Disease Assessment Scale-cognitive subscale and the Neuropsychiatric Inventory at baseline and 6 and 12 weeks
Magnetic resonance imaging (MRI) and resting-state functional MRI at baseline and 12 weeks.

Results:

Figure 1. ADAS-cog (A) and NPI-FS (B) scores in the PBM (blue line) and UC (red line) groups by time. Lower scores on both measures indicate better function.

After 12 weeks, there were improvements in ADAS-cog and in the NPI.

A summary measure of the individual domain scores: higher NPI-FS scores reflect more severe/more frequent dementia-related behavior.

In this study, the PBM group improved an average of -12.3 points on the NPI-FS after 6 weeks and -22.8 points after 12 weeks of treatments.

By comparison, previous pharmacological trials of donepezil reported no difference from placebo on behavioral symptoms measured by the NPI and no difference on quality of life.

Importantly, there were no adverse effects associated with the PBM treatments in this or Saltmarche et al.’s study. In contrast, many of the Food and Drug Administration approved pharmacological treatments for dementia have been associated with substantial side effect burden, such as diarrhea, vomiting, nausea, and fatigue.

Figure 2 Increased cerebral perfusion with the Vielight Neuro Gamma

The third finding of this study is that cerebral perfusion (CBF) increased after 12 weeks in the PBM group compared to the UC group. This finding is consistent with previous reports of PBM-related increases in local CBF, oxygen consumption, total hemoglobin, a proxy for increased rCBF, rCBF, and increased oxygenated/decreased deoxygenated hemoglobin concentrations.

Interestingly, the PBM-related increases in perfusion were most prominent in the parietal ROIs. This may relate to the fact that the Vielight Neuro Gamma used in this study had three transcranial LED clusters over the parietal lobe and only one transcranial LED cluster over the frontal lobe. This finding may also be explained by the report that NIR light penetrates more deeply through the parietal lobe compared to the frontal lobe due to the higher power density of the rear transcranial LED modules .

Connectivity changes in the DMN have been described in populations at risk for AD as well as in patients with AD. Because decreased DMN connectivity is a common finding in resting-state connectivity studies of AD, it is significant that there was increased functional connectivity between the PCC and the LP nodes of the DMN in the PBM group after 12 weeks compared to the UC group.

There have been reports of increased functional connectivity in the DMN after pharmacological treatments in mild-to-moderate AD patients. There have also been studies that reported changes in functional connectivity after nonpharmacological intervention in patients with MCI. To our knowledge, this is the first report of functional connectivity changes in dementia patients after a nonpharmacological intervention.

Neuro RX Gamma – Phase 3 Clinical Trial

We are running a Phase 3 Alzheimer’s Clinical Trial to test the efficacy of brain photobiomodulation via the Vielight Neuro RX Gamma (Neuro Gamma) for FDA approval. This would add to our roster of Health Canada Medical Device license for the acceleration of the recovery of upper respiratory symptoms in viral infections, such as COVID-19 with the RX-Plus (X-Plus 4).

Conclusion

Alzheimer’s disease poses a significant challenge to global health, necessitating innovative approaches for treatment and management. Brain photobiomodulation represents a promising therapeutic modality that harnesses the power of light to stimulate cellular function and promote neuroprotection. While further research is warranted, the emerging evidence suggests that PBM may offer hope for individuals living with AD and their families.

In conclusion, brain photobiomodulation holds tremendous potential as a non-invasive, safe, and effective intervention for Alzheimer’s disease. By addressing underlying pathological mechanisms and promoting neuronal health, PBM may usher in a new era of treatment for this devastating condition.

References:

De Taboada L, et al. (2011). Transcranial laser therapy attenuates amyloid-β peptide neuropathology in amyloid-β protein precursor transgenic mice. Neurobiology of Aging, 32(1), 25-28.
Yang X, et al. (2018). Transcranial low-level laser therapy improves cognitive deficits and inhibits microglial activation after controlled cortical impact in mice. Neurophotonics, 5(1), 015001.
Saltmarche AE, et al. (2017). Significant Improvement in Cognition in Mild to Moderately Severe Dementia Cases Treated with Transcranial Plus Intranasal Photobiomodulation: Case Series Report. Journal of Alzheimer’s Disease, 60(2), 1-13.
Vemuri P, Jones DT, Jack CR, Jr. Resting state functional MRI in Alzheimer’s Disease. Alzheimers Res Ther 2012;4:2
Sole-Padulles C, Bartres-Faz D, Llado A, et al. Donepezil treatment stabilizes functional connectivity during resting state and brain activity during memory encoding in Alzheimer’s disease. J Clin Psychopharmacol 2013;33:199–205.
Goveas JS, Xie C, Ward BD, Wu Z, Li W, Franczak M. Recovery of hippocampal network connectivity correlates with cognitive improvement in mild Alzheimer’s disease patients treated with donepezil assessed by resting-state fMRi. J Magn Reson Imaging 2011;34:764–773.
Li W, Antuono PG, Xie C, et al. Changes in regional cerebral blood flow and functional connectivity in the cholinergic pathway associated with cognitive performance in subjects with mild Alzheimer’s disease after 12-week donepezil treatment. Neuroimage 2012;60:1083–1091.

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Are Neurons extra sensitive to light energy?

Vielight Main — Fri, 30 May 2025 14:27:13 +0000

Are Neurons Extra Sensitive to Light Energy?

The idea that light can influence the brain isn’t science fiction, it’s science. In recent years, the field of photobiomodulation (PBM) has uncovered how light energy, particularly in the red and near-infrared spectrum, can interact with our cells in surprisingly therapeutic ways. But are neurons, our brain’s most vital and complex cells, especially sensitive to this kind of energy?

What is Photobiomodulation?

Photobiomodulation refers to the use of specific wavelengths of light to stimulate cellular function, most notably through mitochondrial mechanisms. The most common wavelengths used are in the red (600–700 nm) and near-infrared (760–1100 nm) range. These wavelengths penetrate biological tissues and are absorbed by intracellular photoreceptors, particularly cytochrome c oxidase (CCO) in mitochondria, leading to increased ATP production, modulation of reactive oxygen species, and changes in gene expression [1].

Why Neurons Might Be More Sensitive

Neurons are highly metabolically active and rely heavily on mitochondrial function. Since they are post-mitotic and do not easily regenerate, their health is tightly linked to mitochondrial performance. This may explain why they respond especially well to light stimulation.

High mitochondrial density: Neurons have a large number of mitochondria to support their energy needs, especially in synapses [2].
Vulnerability to oxidative stress: The brain uses about 20% of the body’s oxygen but comprises only ~2% of its mass. PBM’s ability to regulate redox balance offers potential neuroprotection [3].
Modulation of neuroinflammation: Light energy has been shown to reduce inflammatory markers and glial activity, both of which affect neuron health [4].

Supporting Evidence

1. Improved Cognitive Function

A randomized controlled trial found that near-infrared PBM applied to the prefrontal cortex improved attention and memory in healthy adults [5].

2. Neuroprotection After Injury

In rodent models of traumatic brain injury, PBM preserved neurons, reduced glial scarring, and stimulated regeneration [6].

3. Functional Imaging Studies

EEG and fMRI studies have shown increased brain activity and connectivity after PBM, suggesting direct effects on neural networks [7].

4. Applications in Neurodegenerative Disorders

Early human studies indicate benefits for Alzheimer’s and Parkinson’s patients, including improved mood, memory, and sleep [8].

Can Light Really Reach the Brain?

The human skull filters out much light, but near-infrared wavelengths, especially in the 810–1070 nm range, can penetrate to the cortex. Studies estimate that enough light reaches cortical tissue to stimulate a biological response, especially when higher-power or pulsed devices are used [9].

Visual Proof: Near-Infrared Light Penetrating the Skull with Vielight Neuro 4

The Vielight Neuro has the deepest penetration in the brain photobiomodulation field. The demonstration video below with a real human skull and the Vielight Neuro clearly demonstrates 810nm light energy with an irradiance of 250 mW/cm2 clearly passing through the skull’s calvaria.

The Vielight Neuro features proprietary Vie-LED technology—highly specialized, custom-engineered LEDs designed to deliver optimal irradiance for brain stimulation without producing excess heat. To ensure safety and efficiency, we’ve intentionally limited the device’s power density to 50% of its maximum potential output. Even still, it features the highest irradiance in the field of brain photobiomodulation according to independent 3rd party tests.

Conclusion

So, are neurons extra sensitive to light energy? Current research strongly suggests yes. Due to their high energy demands and mitochondrial density, neurons are well-positioned to benefit from photobiomodulation. Whether enhancing cognitive performance, protecting against injury, or slowing neurodegeneration, PBM appears to offer a non-invasive, promising method to support Brain wellness.

References

Hamblin, M.R. (2016). Shining light on the head: Photobiomodulation for brain disorders. BBA Clinical, 6, 113–124. https://doi.org/10.1016/j.bbacli.2016.09.002
Attwell, D., & Laughlin, S.B. (2001). An energy budget for signaling in the grey matter of the brain. Journal of Cerebral Blood Flow & Metabolism, 21(10), 1133–1145. https://doi.org/10.1097/00004647-200110000-00001
Sies, H. (2015). Oxidative stress: A concept in redox biology and medicine. Redox Biology, 4, 180–183. https://doi.org/10.1016/j.redox.2015.01.002
Salehpour, F., et al. (2018). Transcranial Photobiomodulation Therapy: A Novel Method for Neuroenhancement. Journal of Photochemistry and Photobiology B, 183, 47–55. https://doi.org/10.1016/j.jphotobiol.2018.04.007
Barrett, D.W., & Gonzalez-Lima, F. (2013). Transcranial infrared laser stimulation produces beneficial cognitive and emotional effects in humans. Neuroscience, 230, 13–23. https://doi.org/10.1016/j.neuroscience.2012.11.016
Xuan, W., et al. (2014). Transcranial low-level laser therapy improves neurological performance in traumatic brain injury in mice. PLOS ONE, 9(1), e86264. https://doi.org/10.1371/journal.pone.0086264
Tian, F., et al. (2016). Transcranial laser stimulation improves human cerebral oxygenation. Lasers in Surgery and Medicine, 48(4), 343–349. https://doi.org/10.1002/lsm.22470
Chao, L.L. (2019). Home Photobiomodulation Treatments on Cognitive and Behavioral Function in Dementia. Journal of Alzheimer’s Disease Reports, 3(1), 241–255. https://doi.org/10.3233/ADR-190135
https://www.vielight.com/blog/irradiance-the-key-to-effective-brain-photobiomodulation/

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Neuro-Optometric TBI Lecture | Vielight (tPBM) Technology | Dr Fitzgerald and Dr. Shidlofsky

Vielight Main — Tue, 15 Apr 2025 16:52:14 +0000

Introduction

Concussions, traumatic brain injuries (TBI), and neurodegenerative conditions present ongoing challenges in neurorehabilitation. During a recent lecture delivered by leading neuro-optometrists Dr. Charles Shidlofsky and Dr. DeAnn Fitzgerald, attendees were introduced to a novel adjunctive modality in neurorehabilitation: the Vielight Neuro, a non-invasive photobiomodulation (PBM) technology designed to deliver near-infrared (NIR) light to the brain.

Why Recovery Outcomes Differ: A Clinical Observation

Dr. Fitzgerald posed a critical question during her lecture: why do individuals with similar brain injuries often experience vastly different recovery outcomes? She pointed to neuroinflammation, mitochondrial dysfunction, and autonomic dysregulation as key variables. Without addressing these foundational issues, traditional rehabilitation efforts—such as vision therapy, vestibular rehabilitation, and cognitive retraining—may be less effective.

The Vielight Neuro: A Tool to Support Neuroplasticity

With her many years of clinical work with the Vielight Neuro, Dr. Fitzgerald proposes the Vielight Neuro as a tool to reach cortical regions and interact with mitochondria, due to its optimal irradiance and 810nm NIR wavelength.

Scientific and clinical observations presented in the lecture highlighted several PBM-supported processes:

ATP Production: Enhanced mitochondrial output for increased cellular energy.
Anti-inflammatory Action: Downregulation of neuroinflammation.
Neuroplasticity Support: Activation of brain-derived neurotrophic factors (BDNF) and synaptic remodeling.
Autonomic Regulation: Shifting from sympathetic dominance to parasympathetic balance, supported by vagus nerve stimulation.

Lecture Case Examples: Application in Clinical Settings

The presenters shared a number of anonymized case observations. In concussion management, application of the Vielight Neuro device prior to or during neuro-vision therapy sessions appeared to correlate with:

Reduced headache frequency and photophobia within weeks
Improvements in reaction time and cognitive performance
Enhanced readiness for traditional therapies like eye tracking and balance training

In one Parkinson’s case, 12 weeks of structured PBM exposure coincided with:

Improved contrast sensitivity
Enhanced gait and balance
Reduced cognitive fatigue

While causality cannot be confirmed, these observational insights supported further exploration.

Scientific Insights from Dr. Lew Lim

Dr. Lew Lim, founder of Vielight, expanded on the underlying science. He referenced functional MRI studies conducted at Baycrest Hospital (University of Toronto) with a new Vielight laser apparatus, in which intranasal and transcranial brain stimulation demonstrated measurable brain-wide responses:

At 150 mW/cm² transcranial, blood-oxygen-level-dependent (BOLD) imaging showed increases in cerebral blood flow and activation.
Optimal results were observed at 10 Hz (alpha) and 40 Hz (gamma) pulse frequencies.

These findings align with earlier data from studies with the Vielight Neuro at the University of Utah and Brigham Young University, which tracked improvements in balance, reaction time, and mood in athletes exposed to repetitive head impacts.

PBM via the Vielight Neuro is theorized to act through:

Nitric oxide release, enabling vasodilation and perfusion
ATP synthesis for cellular energy
Activation of transcription factors such as NF-kB and Nrf2
Support of mitochondrial efficiency and reduction of oxidative stress

Potential Applications Discussed

The speakers emphasized the need for further study but highlighted areas under active investigation, including:

Visual Snow Syndrome
Long COVID-related brain fog
Stroke-related visual field issues
Neurodegenerative conditions such as Parkinson’s and mild cognitive impairment

Device Use: In-Clinic and at Home

Due to the device’s sensitive construction, most use occurs in-clinic. However, practitioners noted that patients are increasingly purchasing the Vielight Neuro Duo for home use under clinical guidance. Additionally, the Vielight Vagus device—targeting the vagus nerve—was discussed for its role in supporting parasympathetic activity and sleep regulation.

Conclusion: A New Frontier in Brain Stimulation

This lecture reinforced that photobiomodulation via the Vielight Neuro is an emerging area of interest in neurorehabilitation. By potentially influencing key pathways related to energy production, inflammation, and brain network reorganization, the technology offers new avenues for enhancing resilience and recovery.

As the field advances through more rigorous research and clinical trials, including studies aiming for FDA clearance, the Vielight Neuro may continue to gain traction as a tool for supporting neurological function across a range of applications.

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How to Improve Cognitive Function and Memory

Benja — Tue, 18 Mar 2025 03:36:09 +0000

Cognitive function and memory are essential for daily life, affecting everything from decision-making and learning to problem-solving and emotional well-being. As we age, cognitive abilities can decline, but science shows that lifestyle choices, mental stimulation, and innovative therapies can help maintain and even enhance brain function.

We invite you to explore proven strategies to improve cognitive function and memory, including diet, exercise, mental training, stress management, and cutting-edge photobiomodulation (PBM) therapy. Keep reading to discover how you can support your Brain wellness and enhance your cognitive performance.

Understanding Cognitive Function and Memory

Cognitive function and memory are fundamental to how we navigate life, influencing our ability to think, learn, and adapt. These brain processes determine how we retain information, solve problems, and make decisions.

While cognitive abilities can naturally decline with age, proactive strategies can help maintain and even improve brain function over time.

What Is Cognitive Function?

Cognitive function refers to the brain’s ability to process information, solve problems, and store knowledge. It encompasses essential mental skills like attention, reasoning, perception, and decision-making, all of which shape how we interact with the world.

Strong cognitive function is crucial for learning new skills, adapting to challenges, and maintaining independence throughout life. Factors such as brain stimulation, physical health, and proper nutrition play a significant role in preserving these abilities and supporting long-term mental performance.

Why Memory Matters for Brain wellness

Memory is a core component of cognitive function, allowing us to recall past experiences, retain new knowledge, and perform daily tasks effortlessly. It enables everything from remembering names and appointments to making complex decisions based on prior experiences.

As we age, memory decline becomes more common, often due to factors like stress, poor sleep, and reduced neural plasticity. However, lifestyle changes, mental exercises, and brain-supporting strategies can help preserve and even enhance memory, keeping the mind sharp and resilient.

Strategies to Improve Cognitive Function and Memory

Improving cognitive function and memory requires a holistic approach that combines healthy habits, mental stimulation, and stress management. Research has shown that simple, consistent lifestyle changes can have a profound impact on Brain wellness, mental clarity, and long-term cognitive resilience.

Below are some of the most effective evidence-based strategies.

Lifestyle Changes for a Healthier Brain

Daily habits play a crucial role in supporting brain function.

Nutrition: Eating a brain-boosting diet rich in antioxidants, omega-3 fatty acids, and essential vitamins supports neuroprotection and mental clarity. Foods like berries, fatty fish, nuts, and leafy greens are known for their cognitive benefits.
Exercise: Regular physical activity improves blood circulation to the brain, promoting better oxygenation and nutrient delivery. Activities like aerobic exercise, strength training, and even walking can enhance memory and mental sharpness.
Sleep: Quality sleep is essential for memory consolidation, cognitive processing, and emotional regulation. Establishing a consistent sleep routine and ensuring 7-9 hours of rest per night can significantly improve brain function.

Mental Exercises to Keep Your Brain Sharp

Just like the body, the brain needs regular exercise to stay strong and agile. Engaging in mentally stimulating activities can enhance cognitive function, improve memory, and promote neuroplasticity, which is the brain’s ability to form new connections and adapt over time.

Cognitive Training: Brain-challenging activities like puzzles, memory games, chess, and problem-solving tasks help strengthen neural pathways, improving focus, reasoning, and information processing.
Lifelong Learning: Continuously acquiring new knowledge—whether through learning a language, picking up a musical instrument, or exploring a new hobby—keeps the brain engaged, fostering cognitive resilience and adaptability.

Stress Management for Better Cognitive Health

Chronic stress can harm cognitive function and memory, leading to difficulties in concentration, decision-making, and mental clarity. Incorporating relaxation techniques into daily life can help protect and enhance mental performance.

Mindfulness & Meditation: Practicing mindfulness and meditation helps reduce cortisol levels, the stress hormone that can impair memory and cognitive processing. Regular meditation has been shown to improve focus, emotional regulation, and overall brain function.
Relaxation Techniques: Engaging in activities like deep breathing exercises, yoga, and spending time in nature promotes mental clarity, relaxation, and a sense of well-being, all of which contribute to better cognitive health.

The Role of Photobiomodulation (PBM) in Cognitive Enhancement

Photobiomodulation (PBM) is a non-invasive therapy that uses specific wavelengths of light to stimulate brain cells and enhance cognitive function.

By delivering near-infrared (NIR) light to targeted brain regions, PBM promotes cellular energy production, reduces inflammation, and supports neuroplasticity—the brain’s ability to form new neural connections.

Scientific research has shown that PBM can:

Improve memory
Enhance focus
Provide neuroprotection against age-related cognitive decline

PBM has the potential to help individuals with brain fog, mild cognitive impairment, and even neurodegenerative conditions by supporting the brain’s natural repair processes.

One of PBM’s key benefits is its ability to reduce oxidative stress and improve mitochondrial function, both of which are essential for brain energy and performance. Additionally, PBM enhances blood circulation and neural communication, further supporting cognitive health.

If you’re new to this innovative technology, check out our guide on light therapy for beginners to learn more about how it works.

Train Your Brain With Vielight Neuro

Maximizing cognitive function requires a well-rounded approach that combines healthy lifestyle choices, mental stimulation, and innovative therapies. While diet, exercise, and brain-training activities help maintain cognitive sharpness, Photobiomodulation (PBM) therapy offers an advanced, science-backed method to enhance brain performance further.

Vielight Neuro is a groundbreaking PBM device designed to support memory, focus, and overall cognitive health. Using patented near-infrared (NIR) technology, it delivers light energy to key brain regions involved in learning and neuroplasticity. This stimulation helps enhance mental clarity, improve neural communication, and promote brain resilience over time.

Explore how Vielight’s innovative PBM technology can help you train your brain!

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MCI and Brain Photobiomodulation | Clinical Results with Vielight Neuro

Vielight Main — Tue, 14 Jan 2025 21:25:39 +0000

Mild Cognitive Impairment (MCI) is a condition that often precedes more severe forms of dementia, such as Alzheimer’s disease (AD).

A recent clinical study by researchers from the University of Toronto investigated whether a non-invasive technique called transcranial photobiomodulation (tPBM), which uses near-infrared light to stimulate brain cells, could improve brain function in individuals with MCI. The study utilized the Vielight Neuro RX Gamma (medical version of the Vielight Neuro Gamma), a cutting-edge device designed to deliver transcranial and intranasal PBM therapy.

FULL DATA PRESENTATION LINK

What is Transcranial Photobiomodulation (tPBM)?

tPBM is a non-invasive treatment that uses near-infrared light to penetrate the skull and stimulate brain cells. This light energy is thought to enhance mitochondrial function—the powerhouse of cells—which can improve energy production and overall Brain wellness. The Vielight Neuro RX Gamma is a specialized device that delivers this light therapy directly to the brain through the scalp and nasal cavity, making it a convenient tool for home-based treatment.

The Study Design

The study involved 14 participants with MCI, who were randomly assigned to either an active tPBM group or a sham (placebo) group. Over six weeks, participants used the Vielight Neuro RX Gamma daily at home. The active group received real near-infrared light therapy, while the sham group received a placebo treatment with no therapeutic effect. Before and after the six-week period, participants underwent a series of tests to measure changes in brain function, including:

Cognitive tests: Trail Making Test (TMT) and Mini-Mental State Examination (MMSE) to assess executive function and general cognitive abilities.
Brain imaging: Structural MRI, resting-state functional MRI (rsfMRI), and Proton Magnetic Resonance Spectroscopy (H-MRS) to evaluate brain structure, connectivity, and metabolic changes.
Blood tests: Analysis of biomarkers related to Alzheimer’s disease and mitochondrial function.

Key Findings

The results showed significant improvements in the active tPBM group compared to the sham group:

Cognitive Function: Participants in the active group performed better on the Trail Making Test (TMT-B), which measures executive function, and showed a trend toward improvement on the MMSE, a general cognitive test.
Brain wellness:
- H-MRS scans revealed a decline in the N-acetyl aspartate to total creatine ratio (NAA/Cr), a marker of neuronal health, suggesting improved brain metabolism.
- Structural MRI showed an increase in the volume of the right thalamus, a brain region involved in sensory and motor signaling.
- Resting-state fMRI demonstrated enhanced connectivity in key brain networks, including the default mode network (DMN) and limbic network, which are critical for memory and emotional processing.
Blood Biomarkers:
- Levels of isoleucine, methionine, and sarcosine—markers linked to Alzheimer’s and amyloid plaque formation—decreased significantly.
- Levels of butyrate and L-carnitine—markers associated with improved mitochondrial function—increased, indicating better cellular energy production.
Plasma Tau: While not statistically significant, there was a notable reduction in plasma tau levels in the active group. Tau is a protein linked to Alzheimer’s progression, and its reduction is a promising sign.

What Does This Mean?

The findings suggest that tPBM, delivered via the Vielight Neuro RX Gamma, may improve executive function, brain connectivity, and mitochondrial health while reducing markers associated with Alzheimer’s disease. These results are particularly exciting because they highlight the potential of a non-invasive, home-based therapy to slow or even reverse cognitive decline in individuals with MCI.

Limitations and Future Directions

While the results are promising, this was a small pilot study with only 14 participants. Larger studies are needed to confirm these findings and explore the long-term effects of tPBM. Additionally, future research could investigate whether tPBM can delay or prevent the progression from MCI to Alzheimer’s dementia.

Conclusion

This study offers hope for individuals with MCI and their families, suggesting that near-infrared light therapy, such as that delivered by the Vielight Neuro RX Gamma, could be a safe and effective way to improve brain function and potentially slow the progression of cognitive decline. As research continues, tPBM may become a valuable tool in the fight against Alzheimer’s disease and other forms of dementia.

This study represents an exciting step forward in the field of non-invasive brain therapies, and the Vielight Neuro RX Gamma stands out as a promising device for delivering these benefits.

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Can Light Penetrate the Skull?

Vielight Main — Wed, 28 Aug 2024 20:54:37 +0000

Can light penetrate the human skull and reach the brain? This question often arises among both skeptics and scientists.

The answer is yes but with caveats; this requires an appropriate wavelength (nm) and sufficient irradiance (mW/cm²) In this demonstration with a real human skull, the Vielight Neuro, emitting 810 nm near-infrared light at an industry-leading irradiance of 250 mW/cm², clearly passes through the skullcap.

With the highest irradiance in the brain photobiomodulation field and the most published research in the industry, Vielight has set the benchmark for depth of penetration and the most published brain photobiomodulation studies.

Watch the video here:

Firstly, why deliver light energy through the skull?

The discovery that red to near infrared light energy produces beneficial effects within neurons is groundbreaking. Near-infrared light stimulates a photosensitive enzyme, cytochrome c oxidase, that’s found within mitochondria – which leads to increased cellular energy, leading to a process known as “brain photobiomodulation”. By stimulating cytochrome oxidase activity, transcranial photobiomodulation increases neuronal energy levels – leading to increased gamma brain oscillations, brain plasticity and cognitive flexibility.^[1]

However, this non-invasive, chemical-free brain enhancing stimulation wouldn’t be possible, if near infrared light energy couldn’t reach the brain in the first place.

810nm light energy penetration through a human skull with the Vielight Neuro.

What is near infrared light energy?

Near infrared light (NIR) energy is part of the electromagnetic spectrum – which are waves (or photons) of the electromagnetic field, radiating through space, carrying electromagnetic radiant energy. At this day and age, several existing technologies depend on the ability of electromagnetic energy to penetrate solid objects. Several examples include WiFi, mobile data, radar and navigation satellites.

Figure 1 The electromagnetic spectrum

The depth or the power of penetration by light energy depends on the wavelength in the electromagnetic spectrum. Thus, the longer the wavelength, the greater the ability for photons to penetrate an object. For example, near infrared light is found around the center of the electromagnetic spectrum.

Does 810 nm or 1064 nm (1070nm) penetrate deeper into the brain?

According to a transcranial brain photobiomodulation (PBM) study by Harvard Medical School, Department of Psychiatry, the 810nm wavelength has been found to be superior to other wavelengths, which includes higher wavelengths in the 1070nm range for penetration and dosimetry.

According to this study by Harvard Medical School, the order of penetration and dosimetry effectiveness is:

810 nm – consistently highest across all age groups and regions
850 nm and 1064 nm – next most effective in most cases
670 nm and 980 nm – lesser deposition overall

This Harvard study is also supported by another brain PBM dosimetry study by leading Chinese universities, comparing 660 nm, 810 nm, 880 nm and 1064 nm. They discovered that the distribution of photon fluence at 660 and 810 nm within the brain was much wider and deeper than 980 and 1064 nm.

The distribution of photon fluence at 660 nm, 810 nm, 980 nm and 1064 nm. Wang P, Li T. “Which wavelength is optimal for transcranial low-level laser stimulation?” J. Biophotonics. 2019; 12:e201800173. https://doi.org/10.1002/jbio.201800173

The differences in dosimetry is supported by a well-established biological principle, the body’s first optical window. While, the 1064 and 1070nm wavelengths are longer and scatter less than 810nm, they are more strongly absorbed by water, which is abundant in biological tissues. This increased absorption by water can lead to reduced photonic availability and tissue penetration despite the longer wavelength, which the Harvard Medical study and Peking Medical University study reveal.

The near infrared window or body’s optical window. Image source: Wang, Erica & Kaur, Ramanjot & Fierro, Manuel & Austin, Evan & Jones, Linda & Jagdeo, Jared. (2019). Safety and penetration of light into the brain. 10.1016/B978-0-12-815305-5.00005-1.

Water Absorption: Light absorption by water increases significantly beyond ~950 nm, and water is abundant in biological tissue. At 1064 nm, absorption by water becomes substantial, which attenuates the light more than at 810 nm. This increased absorption reduces the effective depth of penetration, especially for energy reaching specific chromophores like cytochrome c oxidase (CCO).
Cytochrome c Oxidase (CCO) Absorption: Mitochondria’s CCO’s absorption spectrum peaks around 810 nm, with a notable decrease in absorption beyond 1000 nm. This means that 810 nm light is more readily absorbed by CCO compared to 1070 nm.

Expanding on the 810nm light penetration study by Harvard Medical School

In order to reach the brain transcranially, NIR light energy must bypass several barriers – skin, blood, water and bone.

In a 2020 study comparing 810nm with 1070nm by researchers from the Harvard Psychiatry Department, they combined similar tissues together to create a simplified head model. This model contains eight different brain tissues: white matter (WM), gray matter (GM), CSF, skull, muscles, skin/muscles, fat, and blood vessels.^[5]

This study involved the simulation of light deposition at five wavelengths commonly used in NIR applications—670, 810, 850, 980, and 1064 (1070) nm. These wavelengths have been widely used in published studies in photobiomodulation, many of which correspond to the absorption spectra of different tissues within the human body.

Figure 3
The average (bars) and peak (dots) energy deposition (penetration) after positioning the LED light source.
The left brain shows the ROIs that receiving the highest (red) and second highest (orange) energy deposition; the right brain shows the energy deposition map on the cortical surface.
(a) fluence at the F3-F4 sites
(b) fluence at the Fp1–FpZ–Fp2 sites

Figure 4
The average (bars) and peak (dots) energy deposition (penetration) after positioning the intranasal light source in the: (a) nostril, (b) mid-nose, and (c) close to the nose ceiling (in proximity of the cribriform plate)
The left brain shows the ROIs that receiving the highest (red) and second highest (orange) energy deposition; the right brain shows the energy deposition map on the cortical surface.
(a) Nostril position
(b) Mid-nose position
(c) Cribiform plate

Figure 5

Plots of the normalized energy deposition results for (a) the nostril illumination, (b) the mid-nose illumination, and (c) the cribriform plate illumination.
All results are simulated with the optical properties at 810 nm.

Conclusively, they found that the wavelength plays an important role in determining the magnitude of the energy deposition. In general, there was a clear trend showing that 810 nm offered the highest light penetration onto the brain, followed closely by 1064 and 850 nm.

Additionally, a study done in 2012 by the State University of New York, Downstate Medical Center, compared the transmission of NIR LED light (830nm) versus visible red LED light (633nm) through soft tissue, bone, water and blood.

Here were their results from their study on the penetration of NIR light through a human head^[3]:

Figure 3. Percent Penetrance of Light through Coronal Sections of Cadaver Skull, Bone Only.

Figure 4. Percent Penetrance of Light through Sagittal Sections of Cadaver Skull with Intact Soft Tissue.

Figure 5. Percent Penetrance of Light through Various Concentrations of Blood.

Figure 6. Percent Penetrance of Light through Human Cheek in vivo.

These findings demonstrate that NIR light measurably penetrates skin, bone and brain tissue in a human head model. On the other hand, there isn’t as much transmission of red light in the same conditions.

As mentioned earlier, quite a few technologies depend on the diffusion of light energy through these barriers. For example, brain imaging technology known as near infrared spectroscopy (NIRS). NIRS involves detecting changes in blood hemoglobin concentrations associated with neural activity within cortical brain tissue. Fundamentally, this technology is based on the penetration of NIR light through the cranium and into the brain, reaching up to 4 cm of depth.

Emphasis on the intranasal channel

The intranasal channel is an important gateway for light energy to reach the ventral prefrontal cortex of the brain. Otherwise, this area is inaccessible through the cranium. Furthermore, the ventral prefrontal cortex plays a role in emotional responses, decision making and self control – which play important roles in performance and mental balance.

Watch how Vielight’s patented intranasal technology can reach deep brain structures through the nasal channel:

MoreMore emphasis on the intranasal channel

Additionally, a study on the intranasal diffusion of NIR light through a human head was done by the Institute of Chemical Sciences and Engineering in Switzerland. This study demonstrated that it is possible to illuminate deep brain tissues transcranially and intranasally.^[4]The measurement of the fluence rate distribution was, once again, carried out on a human cadaveric head.

Figure 7 View on the 3D mesh of the skull

This study quantifies the light distribution within brain tissue when illuminating from the nasal cavity with a controlled energy deposition.

Figure 8 (a) Fluence rate distribution at 671 nm. (b) Fluence rate distribution at 808 nm.

The results obtained from the study suggests that light at 810 nm is the better choice. This is due to less absorption and reduced scattering at 810 nm in all tissue types. The increased light propagation at the 810 nm wavelength improves the penetration and diffusion rate of photons into deeper brain regions.

Figure 9 Transmission of light energy through a human cadaver with the Vielight Neuro.

Conclusion

The penetration of light energy into the brain is highly dependent on the wavelength. In light of this, several studies support the ability of near infrared light (808 – 820nm) to penetrate through the skull and up to 4 cm into brain tissue. Thus, these studies help to answer the question: “Can light penetrate the brain?” with a “Yes.”

Figure 9 The light penetration difference among different wavelengths and the effects on cellular mechanisms.

Only the wavelengths in the near-infrared window of 600–850nm is absorbed by the mitochondrial electron transfer chain and leads to upregulation of the neuronal respiratory capacity. Source : Mol Neurobiol. 2018 Aug; 55(8): 6601–6636.

References

Gonzalez-Lima, F; Barrett, Douglas; “Augmentation of cognitive brain functions with transcranial lasers”, Frontiers in Systems Neuroscience : doi:10.3389/fnsys.2014.00036
Smith, Andrew M.; Mancini, Michael C.; Nie, Shuming (2009). “Bioimaging: Second window for in vivo imaging”. Nature Nanotechnology. 4(11): 710–711. doi:1038/nnano.2009.326. ISSN 1748-3387. PMC 2862008
Jagdeo JR, Adams LE, Brody NI, Siegel DM (2012) Transcranial Red and Near Infrared Light Transmission in a Cadaveric Model. PLoS ONE 7(10): e47460. https://doi.org/10.1371/journal.pone.0047460
Pitzschke, Andreas & Lovisa, B & Seydoux, O & Zellweger, M & Pfleiderer, M & Tardy, Y & Wagnières, Georges. (2015). Red and NIR light dosimetry in the human deep brain. Physics in medicine and biology. 60. 2921-2937. 10.1088/0031-9155/60/7/2921.
Yuan Y, Cassano P, Pias M, Fang Q. Transcranial photobiomodulation with near-infrared light from childhood to elderliness: simulation of dosimetry. Neurophotonics. 2020 Jan;7(1):015009. doi: 10.1117/1.NPh.7.1.015009. Epub 2020 Feb 24. PMID: 32118086; PMCID: PMC7039173.

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Vielight Neuro vs PBM Helmets: Published Studies and Irradiance

Vielight Main — Mon, 01 Apr 2024 12:21:51 +0000

As the original inventors of home-use brain photobiomodulation technology in 2014, we learned that effective brain photobiomodulation is not simple.

Delivering the optimal amount of light energy into the brain in a safe and effective manner takes considerable research and engineering.

Here are the reasons behind the Neuro’s unique patented design.

Full transcranial coverage with an intranasal advantage

The Vielight Neuro is engineered for coverage by design, not by quantity. A small number of high-output Vie-LEDs, shaped to bypass hair, are engineered so that natural scattering in the scalp, skull and cerebrospinal fluid, (the brain consists of 70-80% water) broaden each beam into a large, overlapping halo. These halos interact to create an effectively full-transcranial footprint with extra focus over Default Mode Network (DMN) hubs.

The system’s intranasal pathway adds what the cranium alone can’t easily reach: via the cribriform plate, light has a short, porous route to ventral/frontobasal structures, completing dorsal-to-ventral continuity.

This physics-led approach avoids the need for hundreds of low-output LEDs that mainly paint the scalp—it uses fewer, stronger, well-placed emitters to deliver a meaningful energy footprint where it matters.

Watch a demonstration video of the Vielight Neuro vs a 1070 nm helmet.
The 810nm beam is invisible to the human eye but the vibrance is filmed by a CMOS camera.

Published clinical research comparisons

Vielight technology is featured in the most published research in the field of brain photobiomodulation by a significant margin and has the deepest penetration in the entire industry.

Be cautious of companies attributing research conducted with Vielight devices or other devices as attainable to their own.

Brain photobiomodulation is parameter-specific and our Vie-LED technology generates a unique laser-like profile and an industry-leading irradiance on specific and important brain networks, like the Default Mode Network.

Other devices cannot easily emulate our efficacy because of our proprietray Vie-LED technology, intranasal and design patents.

The table below is a benchmark studies published comparison against other random PBM helmets.

Technology	Form Factor	Research	Manufacturer	Medical Grade
Vielight Neuro (Vielight)	Modular	23 published (17 ongoing)	Vielight, Canada	Yes
Weber Medical LED Infrared Helmet	Helmet	0 published	Suyzeko, China (Private-labelled)	–
Neuradiant 1070 (Neuronic)	Helmet	3 published	Suyzeko, China (Private-labelled)	–
Suyzeko PBM Helmet (Suyzeko)	Helmet	1 published	Suyzeko, China	–

*Data as of Sept 2025

Irradiance (Surface Power Density) Comparisons

Irradiance / Power Density Comparison

Vie-LED technology is unique and is engineered to generate a laser-like irradiance profile but with the safety of LEDs.

The PBM Foundation benchmarked the Vielight Neuro 3 against two PBM helmets, the Suyzeko NIR helmet and Neuronic Neuradiant twice, as case studies for their testing program to standardize irradiance reporting.

MegaLab and Optronic Lab, photonics engineering firms, conducted the tests:

When compared against the irradiance of peak natural sunlight (which is free) our Vielight Neuro generates 200-300% the irradiance of sunlight without the negative side effects of UV rays. The tested Neuronic and Suyzeko helmets generated less than 12% of sunlight’s peak irradiance.

A 2024 systematic review that screened 2,133 records and included 97 brain PBM studies reports that irradiance (power density) was typically ~250 mW/cm². The Vielight Neuro with an independently measured irradiance of 180-333 mW/cm², is mostly inline with the irradiance used in these studies, which included lasers. However, the Neuronic and Suzyeko helmets generated less than 5% of the average irradiance used over 97 analyzed brain PBM studies.

Source	Independently measured irradiance	Manufacturer	% of Typical Brain-PBM Irradiance (≈250 mW/cm²)
Vielight Neuro (Vielight)	180-350 mW/cm²	Vielight, Canada	80–160%
Neuradiant 1070 (Neuronic)	≈9 mW/cm²	Suyzeko, China (Private-labelled)	≈4%
Suyzeko PBM Helmet (Suyzeko)	5 mW/cm²	Suyzeko, China	3%
Natural Sunlight	100 mW/cm²	Free	40%

Data Source: The PBM Foundation’s Device Testing Portal ( Link 1 | Link 2 )

**Note: The irradiance of sunlight is approximately 100 mW/cm² at sea level on a clear day.

Optimizing NIR Energy Delivery into the Brain

Delivering NIR light energy (810-1100nm) into the brain is difficult, especially with hair, scalp and body tissue.

There are several important physics-related factors regarding delivering NIR energy successfully into the brain.

Figure: Penetration of 810nm energy through a skull with the Vielight Neuro.

Image source: Uniformed Services University.

Sufficient irradiance.

Irradiance is defined as the concentration of light energy landed on a surface. (mW/cm²)

Sufficient irradiance is required for NIR light energy to penetrate the skin and skull, besides wavelength.

An optimal amount of irradiance is one of the most important metrics for effective brain photobiomodulation.

Figure: The body's optical window

Image source: Wang, Erica & Kaur, Ramanjot & Fierro, Manuel & Austin, Evan & Jones, Linda & Jagdeo, Jared. (2019). Safety and penetration of light into the brain. 10.1016/B978-0-12-815305-5.00005-1.

The proper wavelength range.

NIR light energy within the 800nm-1100nm wavelength range falls within the body’s optical window and a well-studied therapeutic effect on cells.

The body’s optical window refers to the range of wavelengths of light that can penetrate human tissues effectively

The 810nm wavelength has the lowest absorbance by tissue, blood, and water, according to a 2020 study by Harvard Medical School.

A wavelength between 800nm-1100nm is ideal for penetration because of the body’s optical window.

Sorry, your browser doesn't support embedded videos.

Video source: Infrared camera capture of Vielight Neuro Alpha footprint and intensity.

Minimizing distance of LEDs from the scalp.

Light energy gets weaker as it travels over distances due to the inverse square law of light.

As light spreads out from a light source, the irradiance (“or concentration of light energy”) decreases rapidly.

Zero distance between LEDs and the scalp is optimal.

The Problems with Helmets

Standard PBM helmets are not optimized for brain photobiomodulation. Here are several reasons why:

Hair as a barrier

The inflexible dome-shape of PBM helmets does not part hair, causing maximal loss through hair absorption.

Helmets are inflexible

Because they are inflexible, they can’t accommodate variations in head sizes and shapes well, introducing distance and rapid energy loss through the inverse square law of light.

Helmets often use many weak, inefficient LEDs

Utilizing many weak LEDs generates a high total power but a weak irradiance. A weak irradiance means that the concentration of landed light energy that lands on the scalp is insufficient to penetrate.

Helmets trap heat – ventilation is an issue

The lack of ventilation in closed helmets leads to heat build up, leading to discomfort or the placebo effect.

The Myth of Total Power

When it comes to brain photobiomodulation, total power output only matters if the NIR light energy has sufficient irradiance to penetrate the skull.

Total power can be increased by using many weak LEDs. Here’s an example: 1 mW x 10,000 LEDs = 10,000 mW total power output but just 1 mW/cm² of irradiance, or just 1/30 of the irradiance of the NIR spectrum of sunlight.

Total power output is not as important as irradiance (power per unit area, mW/cm²). This position misrepresents a key principle of effective light delivery in PBM, especially when targeting deep brain structures. Let’s break down why irradiance is the critical parameter for meaningful transcranial photobiomodulation.

Irradiance, Not Just Total Power, Drives Efficacy

The depth of penetration and the stimulation of mitochondrial chromophores like cytochrome c oxidase depend on a sufficient irradiance threshold at the tissue interface. If the irradiance is too low, especially at the scalp, the photons do not reach deeper cortical or subcortical targets effectively—even if total emitted power is high.

More LEDs with lower irradiance increase coverage but do not compensate for low penetration. This limitation—they may increase coverage, but they do not enhance penetration unless irradiance per diode is sufficiently high.

The Vielight Neuro | Modular Engineering

The Vielight Neuro’s patented transcranial-intranasal design is engineered for optimal NIR energy transmission, minimal heat generation and maximum comfort.

Here are the reasons why our brain photobiomodulation technology is featured in the most published studies globally.

Factor	Engineering Response
Distance of NIR energy source from the scalp	Vie-LEDs are shaped to maximize contact with the scalp and minimize hair interference.
Sufficient irradiance	Vie-LEDs generate an industry-leading 100-300 mW/cm² of irradiance. Our patented LEDs generate a laser-like energy profile with focusing lenses to penetrate the skull Our irradiance measurements are verified through independent testing and upheld through medical grade manufacturing certification standards.
Variations in head sizes and shapes	Adjustable bands and modules enable greater fit and contact.
Ventilation	Modular form factor enables ventilation, preventing heat buildup.
Targeting Different Brain Networks	Our transcranial modules are adjustable, enabling the diodes to be positioned over different scalp locations.

Medical Device Standards

Vielight is the only North American photobiomodulation device manufacturer that is classified as a medical device manufacturing company, certified under ISO 13485, MDSAP and MDR. Our technology is FDA and Health Canada registered.

Over the years, Vielight has released more than 100,000 devices into the market. There have been no reports of significant adverse events attributed to our products. This is also supported by the large, randomized control clinical trials using Vielight products.

We manage the power of our LEDs to put care and safety first while pursuing optimal efficacy. We make no medical claim unless supported by scientific evidence.

Validation via Research

At Vielight, we understand the need to validate the engineering theory behind our devices with scientific data. A simple idea like placing LEDs on your head can turn surprisingly complex when taking different parameters into account, like the pulse rate, wavelength and power density to maximize efficacy.

With that in mind, we’ve invested heavily in research and clinical trials over the years.

For a full list of published research that used our devices: Link

We are grateful to all the research institutions we’ve collaborated with over the years and look forward to a bright future of discoveries together.

Light-Based Terminology

Power density (mW/cm²)

Power density is the amount of light energy emitted directly from the source.

Power density can be hindered by distance and hair and is not an accurate indication.

Irradiance (mW/cm²)

Irradiance is the amount of light energy landed on a surface from the source.

While surface radiant power density and radiant power density share the same measurement unit mW/cm², they are not equivalent.

Surface radiant power density gives an accurate picture of how much energy the scalp receives.

Total power

Total power is defined as the total amount of energy emitted over a period of time by all light sources.

Many weak inefficient LEDs can generate a high total power but if the surface radiant power density is too low and if blocked by hair, light energy won’t penetrate the skull.

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What is regenerative medicine?

Juan Iriart — Tue, 12 Mar 2024 18:31:02 +0000

Is Photobiomodulation a Regenerative Medicine?

Regenerative medicine aims to restore damaged tissues and organs by stimulating the body’s natural healing processes.

While treatments like stem cell therapy and tissue engineering are well known in this field, emerging technologies such as photobiomodulation (PBM) are gaining attention for their potential role in regeneration, particularly in Brain wellness and neurological recovery.

But is photobiomodulation a regenerative medicine? This article will explore PBM’s mechanisms, its ability to support cellular repair, and how it aligns with regenerative medicine principles. Read on to discover its potential benefits!

What Is Regenerative Medicine?

Regenerative medicine is a field of healthcare focused on restoring damaged tissues and organs by stimulating the body’s natural healing abilities. It aims to repair, replace, or regenerate cells, offering innovative solutions for conditions that traditional treatments may not fully address.

By leveraging biological mechanisms, regenerative medicine seeks to enhance recovery and improve long-term health outcomes. Its applications range from treating injuries and neurodegenerative diseases to promoting overall tissue regeneration and functional restoration.

Common Approaches in Regenerative Medicine

Regenerative medicine encompasses a variety of innovative approaches aimed at restoring function and promoting healing at a cellular level.

Here are some of the most common strategies driving progress in this field.

Stem Cell Therapy – Uses stem cells to replace damaged tissues and promote regeneration.
Tissue Engineering – Combines biomaterials and cells to create functional tissues for medical use.
Biologics – Includes growth factors, proteins, and gene therapies to accelerate tissue repair and healing.

Could photobiomodulation be the next breakthrough in regenerative medicine? Let’s explore how it works.

How Photobiomodulation (PBM) Works

Photobiomodulation (PBM) is a non-invasive therapy that uses specific wavelengths of light to stimulate biological processes at the cellular level. When light penetrates the skin and reaches targeted tissues, it interacts with mitochondria—the energy centers of cells—enhancing their ability to produce ATP (adenosine triphosphate), the fuel necessary for cellular function and repair.

PBM plays a fundamental role in cellular repair and regeneration by boosting mitochondrial activity. It helps reduce oxidative stress and inflammation, two key factors in tissue damage and aging.

Additionally, PBM has been shown to enhance neuroplasticity, improve circulation, and accelerate recovery, making it a promising tool in regenerative medicine, particularly for Brain wellness and neurological conditions.

Can PBM Be Considered Regenerative Medicine?

Research suggests that photobiomodulation (PBM) has significant potential in regenerative medicine, particularly for neurological conditions.

Studies have shown that PBM may aid in stroke recovery by reducing inflammation and promoting cellular repair. Additionally, PBM has been linked to improvements in neurodegenerative diseases like Alzheimer’s and Parkinson’s, helping to enhance cognitive function and slow disease progression.

Scientific findings further support PBM’s role in neuroprotection and tissue repair.

A 2022 study published in Frontiers in Medical Technology (Near-Infrared Photobiomodulation of Living Cells, Tubulin, and Microtubules In Vitro) demonstrated that PBM influences cellular structures, promotes microtubule reorganization, and balances neural activity, key factors in brain regeneration.

These findings reinforce the idea that PBM can help maintain Brain wellness, repair damaged neural networks, and enhance overall cognitive function.

Benefits of PBM in Regenerative Medicine

Photobiomodulation (PBM) is emerging as a powerful tool in regenerative medicine, offering a non-invasive approach to supporting tissue repair and Brain wellness. By stimulating cellular activity with near-infrared light, PBM helps improve cognitive function, accelerate recovery, and promote overall well-being.

Here are some key benefits:

Improved Brain wellness and Neuroplasticity: PBM enhances cognitive function and mental clarity by promoting neuroplasticity—the brain’s ability to reorganize and form new connections. This can be beneficial for individuals recovering from neurological conditions or looking to optimize brain performance.
Enhanced Recovery from Injury: PBM helps reduce inflammation and oxidative stress, two major barriers to healing. By stimulating mitochondrial activity, it accelerates cellular repair, making it useful for recovery after brain injuries, strokes, or neurodegenerative conditions.
Non-Invasive and Safe Alternative: Unlike many regenerative therapies that require surgery or drug treatments, PBM offers a safe, non-invasive solution with minimal risks. It provides a scientifically backed way to support regeneration without the need for complex medical interventions.

Photobiomodulation’s potential in regenerative medicine is clear, but how can you integrate this groundbreaking technology into daily life? That’s where Vielight Neuro comes in.

Vielight Neuro: Bringing Regenerative Benefits to Everyday Life

As photobiomodulation (PBM) continues to gain recognition in regenerative medicine, Vielight Neuro stands at the forefront of innovation. Recognized as the world’s most researched brain PBM device, it’s designed to enhance cognitive function, neuroplasticity, and overall Brain wellness through cutting-edge technology.

With its medical-grade design and research-backed efficacy, Vielight Neuro makes advanced brain regeneration accessible for everyday use.

Explore how PBM technology can help optimize your Brain wellness and bring the benefits of regenerative medicine into your daily life. Schedule a free video consultation with one of our experts to get your questions answered.

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What is Neurotech?

Juan Iriart — Sun, 10 Mar 2024 10:37:44 +0000

What is Neurotech? Discover Photobiomodulation’s Role in Brain Function

Neurotech, or neurotechnology, encompasses tools and innovations that interact with or enhance brain function. These advancements are transforming healthcare by offering solutions for neurological disorders like depression, Alzheimer’s, and anxiety.

In addition to healthcare, Neurotech drives cognitive enhancement, improving memory, focus, and mental clarity. It’s also gaining popularity in wellness for promoting stress reduction and emotional balance.

This article explores the fascinating world of Neurotech, focusing on photobiomodulation, its role in Brain wellness, and how Vielight is leading the way with innovative, non-invasive solutions.

Types of Neurotech

Neurotech encompasses a diverse range of technologies, each designed to interact with the brain in unique ways. These innovations are revolutionizing how we understand and enhance brain function. Here are the main types:

Brain-Computer Interfaces (BCI): These systems establish a direct connection between the brain and external devices, allowing users to control computers or prosthetics using brain signals. BCIs hold immense potential for individuals with disabilities, offering new ways to restore mobility and communication.
Neurostimulation Devices: These devices use electrical or magnetic stimulation to modulate neural activity, helping to treat conditions like chronic pain, depression, and epilepsy. By influencing brain circuits, neurostimulation enhances brain function and restores balance.
Photobiomodulation (PBM): A non-invasive approach that uses specific wavelengths of light to stimulate cellular processes in the brain. PBM improves cognitive function, supports mental clarity, and promotes overall Brain wellness, making it a standout innovation in Neurotech.

Each type plays a fundamental role in advancing Brain wellness and wellness, offering hope and solutions for diverse needs.

Applications of Neurotech

Neurotech offers groundbreaking applications across various fields, improving lives through innovative solutions. Here are three key areas where its impact is most notable:

Healthcare

Neurotech is transforming healthcare by offering innovative solutions for neurological conditions like depression, anxiety, and Alzheimer’s. These technologies help restore brain function by targeting and modulating specific neural pathways, improving patients’ quality of life and delivering non-invasive alternatives to traditional treatments.

Cognitive Enhancement

With Neurotech, individuals can enhance their cognitive abilities, including memory, focus, and mental clarity. These advancements empower users to achieve peak mental performance, whether in professional environments or daily tasks, making them invaluable for those seeking to optimize brain function.

Wellness

In the wellness space, Neurotech promotes mental calmness and reduces stress by stimulating the brain’s natural relaxation responses. This makes it a powerful tool for achieving emotional balance, enhancing overall well-being, and supporting a healthier, more focused mindset.

Delve deeper into the scientific evidence supporting these exciting applications by exploring our dedicated section on published research with Vielight technology.

Photobiomodulation (PBM) and Neurotech

Photobiomodulation (PBM) is a specialized subfield of Neurotech that uses specific wavelengths of light to stimulate cellular processes in the brain. By enhancing cellular energy production, PBM promotes better brain function and supports neural repair.

This non-invasive approach targets key brain regions through light penetration, improving cognitive abilities, mental clarity, and overall Brain wellness. PBM’s ability to stimulate neural activity makes it a valuable tool for addressing various neurological and cognitive challenges.

Vielight has pioneered the development of home-use PBM devices, combining advanced technology with accessibility. Their innovative products, backed by extensive research, offer an effective and convenient way to harness the benefits of PBM for Brain wellness and wellness.

Non-Invasive Neurotech for the Future

The demand for non-invasive Neurotech is rapidly growing as people seek safer, more accessible solutions for improving Brain wellness. Devices like Vielight’s Neuro series exemplify this trend, offering effective technology without the need for surgical procedures or complex treatments.

Accessible, medical-grade technology is essential for addressing cognitive challenges and enhancing mental performance. Non-invasive devices provide a practical and user-friendly way to improve focus, memory, and overall brain function, empowering users to take charge of their mental well-being.

Vielight’s innovative approach combines scientific rigor with convenience, making advanced brain photobiomodulation available to a wider audience. This shift toward non-invasive solutions is shaping the future of Neurotech, bringing transformative Brain wellness technologies into everyday life.

Explore the Future of Brain wellness with Vielight

Neurotech is revolutionizing the way we approach Brain wellness, offering innovative tools to enhance cognitive function, mental clarity, and overall well-being. As a leading pioneer in the field, Vielight’s photobiomodulation technology exemplifies the potential of non-invasive solutions to improve brain function.

If you’re ready to experience the benefits of Neurotech, Vielight’s PBM devices are an excellent place to start. Backed by scientific research and designed for home use, these products empower you to take control of your mental wellness and cognitive performance.

Explore Vielight’s groundbreaking solutions today and discover how they can help you unlock your brain’s full potential.

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40Hz Gamma Neuromodulation in Alzheimer’s Research | Brain Photobiomodulation and Visual Cortex Stimulation

Vielight Main — Wed, 31 May 2023 15:06:58 +0000

The Ongoing Search for Effective and Accessible Treatments for Alzheimer’s Disease

Alzheimer’s disease (AD) is the most common type of dementia in elderly individuals worldwide (Wilson et al., 2012). The disease is characterized by neurodegeneration, tissue changes in the brain, (including amyloid-containing plaques and tangles of hyperphosphorylated tau protein), severe cognitive decline and in many cases, neuropsychiatric symptoms. The search for effective, safe and accessible treatments remains largely elusive. The currently approved drugs have considerable side effects, reducing compliance and some require increased medical follow-up and brain imaging, reducing the accessibility of the treatment to many.

Gamma Modulation as a Potential Treatment for Alzheimer’s Disease

Brain cells, also known as neurons, communicate with each other through electrical signals that produce patterns called brain waves. Of the 5 different types of brain waves, gamma waves are the fastest brain waves. They range from 30 to 100 Hez. Gamma brain waves are linked to cognitive functioning, learning, memory, and information processing.

Abnormal brain waves have been observed in humans with Alzheimer’s Disease (AD), including decreased power of Gamma waves.

In a landmark study, MIT demonstrated that 40Hz visual flashing resulted in improvements in memory and learning in a mouse model of AD. Decreased amyloid plaques and less brain atrophy were also noted. This 40Hz modulation is believed to increase non-inflammatory microglia, which work to remove the pathological amyloid plaque buildup. Additionally, 40 Hz modulation may increase the decreased levels of gamma in patients with AD.

Delivering Gamma Neuromodulation via Brain Photobiomodulation

Photobiomodulation is an innovative way to modulate gamma waves in the brain. The Vielight Neuro Gamma is the first and remains the only commercially-available brain photobiomodulation device to demonstrate statistically significant neuromodulation. This is attributable to our Vie-LED technology, which delivers a laser-like irradiance on key brain networks.

FULL NEUROMODULATION STUDY WITH VIELIGHT NEURO GAMMA

The key randomized, sham-controlled study demonstrated that delivery of 40Hz 810nm NIR energy on using the Vielight Neuro Gamma significantly increases the power of the higher oscillatory frequencies of gamma, alpha and beta and reduces the power of the slower frequencies of delta and theta in subjects in resting state. These changes were seen after a single session of PBM with the Neuro Gamma and were significantly different when compared to sham stimulation.[1] This study clearly demonstrated that 40 Hz pulsed PBM is able to modulate neuronal oscillations and increase the power of gamma in the brain.

In further support of the benefits of 40 Hz pulsed PBM for patients with AD, an independent study conducted by the The University of California San Francisco demonstrated that 12 weeks of at-home use of the Neuro Gamma in dementia patients produced improvements in mental acuity, increased cerebral perfusion and increased connectivity between the posterior cingulate cortex and lateral parietal nodes within the Default-Mode network [2].

The other benefits of brain photobiomodulation

While there are multiple ways to produce neuromodulation and increase levels of gamma in the brain, neuromodulation through pulsed photobiomodulation produces additional benefits not provided by other modalities, that would be of significant benefit to patients with AD.

Improved Mitochondrial Function

Photobiomodulation has been shown to improve mitochondrial function, resulting in increased ATP production. Mitochondrial dysfunction occurs very early in the pathogenesis of AD, and preventing this dysregulation via PBM may be of significant benefit for individuals with AD, as well as those at risk of developing AD.

Increased Blood Flow

PBM results in increased release of Nitric Oxide (NO). NO is a powerful neurotransmitter with multiple properties, one of which being vasodilation. This has been linked with increased oxygenation in the brain.

Improved Neuroprotection

A wide variety of evidence suggests that PBM can be utilized for neuroprotection as a pre-emptive measure to protect cells from future damage and reduce ongoing damage and promote their survival and longevity. [3,4,5,6]

Increased Neurogenesis and Synaptogenesis

Brain photobiomodulation has been shown to promote both synaptogenesis and neurogenesis, as evidenced through increased levels of brain derive neurotrophic factor (BDNF). [7,8]

Conclusion

Neuromodulation to increase gamma oscillations in the brain appears to produce significant clinical benefits for AD. While such neuromodulation may be achieved in more than one way, 40Hz neuromodulation via PBM has been shown to produce additional cellular benefits that are of particular relevance to patients with AD.

References

[1] Zomorrodi, Reza & Loheswaran, Genane & Pushparaj, Abhiram & Lim, Lew. (2019). Pulsed Near Infrared Transcranial and Intranasal Photobiomodulation Significantly Modulates Neural Oscillations: a pilot exploratory study. Scientific Reports. 9. 10.1038/s41598-019-42693-x.

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[3] Liang J, Liu L, Xing D. Photobiomodulation by low-power laser irradiation attenuates Abeta-induced cell apoptosis through the Akt/GSK3beta/beta-catenin pathway. Free Radic Biol Med. 2012;53:1459–1467. [PubMed] [Google Scholar][4] Eells JT, Henry MM, Summerfelt P, Wong-Riley MT, Buchmann EV, Kane M, Whelan NT, Whelan HT. Therapeutic photobiomodulation for methanol-induced retinal toxicity. Proc Natl Acad Sci U S A. 2003;100:3439–3444

[5] Wong-Riley MT, Liang HL, Eells JT, Chance B, Henry MM, Buchmann E, Kane M, Whelan HT. Photobiomodulation directly benefits primary neurons functionally inactivated by toxins: role of cytochrome c oxidase

[6] Huang YY, Nagata K, Tedford CE, Hamblin MR. Low-level laser therapy (810 nm) protects primary cortical neurons against excitotoxicity in vitro. J Biophotonics. 2014;7:656–664. [PMC free article] [PubMed] [Google Scholar][7] Meng C, He Z, Xing D. Low-level laser therapy rescues dendrite atrophy via upregulating BDNF expression: implications for Alzheimer’s disease. J Neurosci. 2013;33:13505–13517. [PMC free article] [PubMed] [Google Scholar][8] YYW Huang Q, Xuan W, Ando T, Xu T, Sharma SK, Kharkwal GB, Hamblin MR. Low Level Light Therapy for Traumatic Brain Injury [Google Scholar]

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